Genetic lesions within the 3a gene of SARS-CoV
Tan, Timothy H.P.
Fielding, Burtram C.
Lim, Seng Gee
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A series of frameshift mutations within the 3a gene has been observed in culture-derived severe acute respiratory syndrome coronavirus (SARS-CoV). We report here that viral RNA from clinical samples obtained from SARS-CoV infected patients also contains a heterogeneous population of wild-type and mutant 3a transcripts.