| dc.contributor.author | Martin-Sancho, Laura | |
| dc.contributor.author | Lewinski, Mary K. | |
| dc.contributor.author | Shaw, Megan L. | |
| dc.date.accessioned | 2022-07-19T13:12:09Z | |
| dc.date.available | 2022-07-19T13:12:09Z | |
| dc.date.issued | 2021 | |
| dc.identifier.citation | Martin-Sancho, L. et al. (2021). Functional landscape of SARS-CoV-2 cellular restriction. Molecular Cell, 81(12), 2656 - 2668. 10.1016/j.molcel.2021.04.008 | en_US |
| dc.identifier.issn | 1097-4164 | |
| dc.identifier.uri | 10.1016/j.molcel.2021.04.008 | |
| dc.identifier.uri | http://hdl.handle.net/10566/7616 | |
| dc.description.abstract | A deficient interferon (IFN) response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been implicated as a determinant of severe coronavirus disease 2019 (COVID-19). To identify the molecular effectors that govern IFN control of SARS-CoV-2 infection, we conducted a large-scale gain-of-function analysis that evaluated the impact of human IFN-stimulated genes (ISGs) on viral replication. A limited subset of ISGs were found to control viral infection, including endosomal factors inhibiting viral entry, RNA binding proteins suppressing viral RNA synthesis, and a highly enriched cluster of endoplasmic reticulum (ER)/Golgi-resident ISGs inhibiting viral assembly/egress. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Cell Press | en_US |
| dc.subject | Covid-19 | en_US |
| dc.subject | Innate immunity | en_US |
| dc.subject | Protein binding | en_US |
| dc.subject | Tumor | en_US |
| dc.subject | Bioscience | en_US |
| dc.title | Functional landscape of SARS-CoV-2 cellular restriction | en_US |
| dc.type | Article | en_US |
