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K21 compound, a potent antifungal agent: Implications for the treatment of fluconazole-resistant HIV-associated Candida species
(Frontiers, 2019-05-24)
Background/objectives: With mucocutaneous candidiasis being highly prevalent in HIV patients, the emergence of fluconazole-resistant Candida species forms a major challenge in treating and eradicating these infections. The ...
Measuring Streptococcus mutans, Streptococcus sanguinis and Candida albicans biofilm formation using a real-time impedance-based system
(Elsevier, 2019-12-20)
Candida albicans and streptococci are amongst the most common fungal and bacterial organisms present in the
oral cavity, with a growing body of evidence implicating C. albicans in increased caries severity and in ...
Candida antifungal drug resistance in sub-Saharan African populations: A systematic review
(Science Navigation Group, 2017)
BACKGROUND: Candida infections are responsible for increased morbidity and mortality rates in at-risk patients, especially in developing countries where there is limited access to antifungal drugs and a high burden of HIV ...
A comparison of susceptibility patterns of oral Candida isolates from South African and Cameroonian HIV- positive populations
(The International Association for Dental Research (IADR), 2012)
METHOD: In this study, Candida isolates were collected from the oral mucosa of 128 South African and 126 Cameroonian HIV-positive patients, by scraping the mouths of consenting patients using sterile cotton swabs. Ethics ...
Strengths and limitations of different Chromogenic Media for the identification of Candida species
(Scientific & Academic Publishing, 2012)
The treatment of invasive candidiasis and other Candida infections with the appropriate antifungal agent is assisted by the identification of Candida isolates to the species level. Rapid and accurate methods of differentiation ...
Drug susceptibility profiles of Candida species isolated from the oral mucosa of HIV-positive West African patients using the TREK Sensititre system
(2013)
BACKGROUND: Candida infections are a common cause of death in
immunocompromised patients. The prevalence and anti-mycotic
drug susceptibility profiles of Candida species from Cameroon in
Africa are unavailable. This ...
HIV/Candida co-infection in Sub-Saharan African women on ART
(Infectious Diseases Society of Southern Africa, the Sexually Transmitted Diseases Society of Southern and the Public Health Association of South Africa., 2013)
INTRODUCTION: Sub-Saharan Africa has 23.5 million cases of HIV and is home to 92% of
the world’s HIV-positive pregnant women of whom 24% die of pregnancy related
complications. Oral candidiasis is a common condition in ...
Proteomic mechanisms of drug resistance in Candida cell membrane fractions
(International Association for Dental Research, 2014)
INTRODUCTION: The African continent has the highest burden of HIV infection, accounting for approximately 65% of new infections globally. Oral candidiasis is a major cause of increased morbidity in HIV-infected individuals ...
Multi-drug resistant (MDR) oral Candida species isolated from HIV-positive patients in South Africa and Cameroon
(Elsevier, 2014)
Candida species are a common cause of infection in immune-compromised HIV-positive individuals, who are usually treated with the antifungal drug, fluconazole in public hospitals in Africa. However, information about the ...
HPLC-MS identification and expression of Candida drug-resistance proteins from African HIV-infected patients
(AIMS Press, 2021-09-10)
The objective of this study was to elucidate the proteomic mechanisms of drug resistance in HIV-infected African patients. Cell membrane fractions from forty oral Candida isolates isolated from African HIV-positive patients ...