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Developing reproducible bioinformatics analysis workflows for heterogeneous computing environments to support African genomics
(Springer Nature, 2018)
Background: The Pan-African bioinformatics network, H3ABioNet, comprises 27 research institutions in 17 African
countries. H3ABioNet is part of the Human Health and Heredity in Africa program (H3Africa), an African-led ...
A uniquely African focus: bioinformatics is a field that has grown exponentially in the past few years, and it is becoming increasingly important to collaborate as the field continues to gather momentum
(2015)
Bioinformatics is a field that has grown exponentially in the past few years, and it is becoming increasingly important to collaborate as the field continues to gather momentum.
Opportunities in Africa for training in genome science
(Academic Journals, 2004)
Genome science is a new type of biology that unites genetics, molecular biology, computational
biology and bioinformatics. The availability of the human genome sequence, as well as the genome
sequences of several other ...
Transcriptomics of the Rooibos (Aspalathus linearis) Species Complex
(MDPI, 2020)
Rooibos (Aspalathus linearis), widely known as a herbal tea, is endemic to the Cape Floristic Region of South Africa (SA). It produces a wide range of phenolic compounds that have been associated with diverse health-promoting ...
Capacity building for whole genome sequencing of Mycobacterium tuberculosis and bioinformatics in high TB burden countries
(Oxford University Press, 2020)
Background
Whole-genome sequencing (WGS) is increasingly used for Mycobacterium tuberculosis (Mtb) research. Countries with the highest tuberculosis (TB) burden face important challenges to integrate WGS into surveillance ...
Ten simple rules for developing bioinformatics capacity at an academic institution
(Public Library of Science, 2021)
Bioinformatics is an applied interdisciplinary field whose primary purpose is to develop and
deploy computational techniques to store, organize, and aid in the analysis and interpretation
of large-scale data obtained ...
Prediction of human-Bacillus anthracis protein–protein interactions using multi-layer neural network
(Oxford University Press, 2018)
Triplet amino acids have successfully been included in feature selection to predict
human-HPV protein-protein interactions (PPI). The utility of supervised learning methods is
curtailed due to experimental data not being ...
The combat-tb workbench: Making powerful Mycobacterium tuberculosis bioinformatics accessible
(American Society for Microbiology, 2022)
Whole-genome sequencing (WGS) is a powerful method for detecting drug resistance, genetic diversity, and transmission dynamics of Mycobacterium tuberculosis. Implementation of WGS in public health microbiology laboratories ...
Human coronavirus OC43 3CL protease and the potential of ML188 as a broad-spectrum lead compound: Homology modelling and molecular dynamic studies
(Springer Nature, 2015)
The coronavirus 3 chymotrypsin-like protease (3CLpro) is a validated target in the design of potential
anticoronavirus inhibitors. The high degree of homology within the protease’s active site and substrate conservation
supports ...
Modelling human protein interaction networks as metric spaces has potential in disease research and drug target discovery
(BMC, 2014)
We have recently shown by formally modelling human protein interaction networks (PINs) as metric
spaces and classified proteins into zones based on their distance from the topological centre that hub proteins are
primarily ...