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RAMICS: Trainable, high-speed and biologically relevant alignment of high-throughput sequencing reads to coding DNA
(Oxford University Press, 2014)
The challenge presented by high-throughput sequencing necessitates the development of novel
tools for accurate alignment of reads to reference sequences. Current approaches focus on using heuristics to map reads quickly ...
FRAGS: Estimation of coding sequence substitution rates from fragmentary data
(BMC, 2004)
Rates of substitution in protein-coding sequences can provide important insights into evolutionary processes that are of biomedical and theoretical interest. Increased availability of coding sequence data has enabled ...