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Careful governance of African biobanks
(Elsevier, 2020)
The Sydney Statement is one of
the first framing documents on the
principles for guiding global health
security. Framing matters because
the funding pool for development
assistance for health is finite and has
plateaued ...
Current perspectives in the discovery of newer medications against the outbreak of Covid-19
(Frontiers Media, 2021)
A rapid and increasing spread of COVID-19 pandemic disease has been perceived
worldwide in 2020. The current COVID-19 disease outbreak is due to the spread of
SARS-CoV-2. SARS-CoV-2 is a new strain of coronavirus that ...
Dispersal dynamics of SARS-CoV-2 lineages during the first epidemic wave in New York City
(Public Library of Science, 2021)
During the first phase of the COVID-19 epidemic, New York City rapidly became the epicenter of the pandemic in the United States. While molecular phylogenetic analyses have previously highlighted multiple introductions and ...
A view on genomic medicine activities in Africa: Implications for policy
(Frontiers Media, 2022)
Genomics policy development involves assessing a wide range of issues extending from
specimen collection and data sharing to whether and howto utilize advanced technologies in
clinical practice and public health initiatives. ...
The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance
(American Association for the Advancement of Science, 2022)
Investment in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing in Africa over the past year has led to a major increase in the number of sequences that have been generated and used to track the ...
Human coronavirus OC43 3CL protease and the potential of ML188 as a broad-spectrum lead compound: Homology modelling and molecular dynamic studies
(Springer Nature, 2015)
The coronavirus 3 chymotrypsin-like protease (3CLpro) is a validated target in the design of potential
anticoronavirus inhibitors. The high degree of homology within the protease’s active site and substrate conservation
supports ...
Modelling human protein interaction networks as metric spaces has potential in disease research and drug target discovery
(BMC, 2014)
We have recently shown by formally modelling human protein interaction networks (PINs) as metric
spaces and classified proteins into zones based on their distance from the topological centre that hub proteins are
primarily ...
Using multiplex amplicon pcr technology to efficiently and timely generate rift valley fever virus sequence data for genomic surveillance
(MDPI, 2023)
Rift Valley fever (RVF) is a febrile vector-borne disease endemic in Africa and continues
to spread in new territories. It is a climate-sensitive disease mostly triggered by abnormal rainfall
patterns. The disease is ...
Changes in subcutaneous adipose tissue microRNA expression in response to exercise training in African women with obesity
(Nature Research, 2022)
The mechanisms that underlie exercise-induced adaptations in adipose tissue have not been
elucidated, yet, accumulating studies suggest an important role for microRNAs (miRNAs). This study
aimed to investigate miRNA ...
Variant-specific introduction and dispersal dynamics of SARS-CoV-2 in New York City – from Alpha to Omicron
(Public Library of Science, 2023)
Since the latter part of 2020, SARS-CoV-2 evolution has been characterised by the emergence of viral variants associated with distinct biological characteristics. While the main
research focus has centred on the ability ...