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A uniquely African focus: bioinformatics is a field that has grown exponentially in the past few years, and it is becoming increasingly important to collaborate as the field continues to gather momentum
(2015)
Bioinformatics is a field that has grown exponentially in the past few years, and it is becoming increasingly important to collaborate as the field continues to gather momentum.
Human coronavirus OC43 3CL protease and the potential of ML188 as a broad-spectrum lead compound: Homology modelling and molecular dynamic studies
(Springer Nature, 2015)
The coronavirus 3 chymotrypsin-like protease (3CLpro) is a validated target in the design of potential
anticoronavirus inhibitors. The high degree of homology within the protease’s active site and substrate conservation
supports ...
Modelling human protein interaction networks as metric spaces has potential in disease research and drug target discovery
(BMC, 2014)
We have recently shown by formally modelling human protein interaction networks (PINs) as metric
spaces and classified proteins into zones based on their distance from the topological centre that hub proteins are
primarily ...
Semantic interrogation of a multi knowledge domain ontological model of tendinopathy identifies four strong candidate risk genes
(Nature Research, 2016)
Tendinopathy is a multifactorial syndrome characterised by tendon pain and thickening, and impaired
performance during activity. Candidate gene association studies have identified genetic factors
that contribute to ...
Computational characterization of iron metabolism in the tsetse disease vector, glossina morsitans: Ire stem-loops
(BMC, 2016)
Iron metabolism and regulation is an indispensable part of species survival, most importantly for
blood feeding insects. Iron regulatory proteins are central regulators of iron homeostasis, whose binding to iron
response ...