dc.contributor.author | Tan, Yee-Joo | |
dc.contributor.author | Tham, Puay-Yoke | |
dc.contributor.author | Chan, Daphne Z. L. | |
dc.contributor.author | Chou, Chih-Fong | |
dc.contributor.author | Shen, Shuo | |
dc.contributor.author | Fielding, Burtram C. | |
dc.contributor.author | Tan, Timothy H.P. | |
dc.contributor.author | Lim, Seng Gee | |
dc.contributor.author | Hong, Wanjin | |
dc.date.accessioned | 2013-11-28T11:03:57Z | |
dc.date.available | 2013-11-28T11:03:57Z | |
dc.date.issued | 2005 | |
dc.identifier.citation | Tan, Y., et al. (2005). The Severe Acute Respiratory Syndrome Coronavirus 3a Protein Up-Regulates Expression of Fibrinogen in Lung Epithelial Cells. Journal of Virology, 79(15): 10083-10087 | |
dc.identifier.issn | 0022-538X | |
dc.identifier.uri | http://hdl.handle.net/10566/883 | |
dc.description.abstract | Here we analyzed the gene expression profile of cells that stably express the severe acute respiratory
syndrome coronavirus (SARS-CoV) 3a protein to determine its effects on host functions. A lung epithelial
cell-line, A549, was chosen for this study because the lung is the primary organ infected by SARS-CoV and
fatalities resulted mainly from pulmonary complications. Our results showed that the expression of 3a
up-regulates the mRNA levels of all three subunits, A , B , and , of fibrinogen. Consequently, the intracellular
levels as well as the secretion of fibrinogen were increased. We also observed increased fibrinogen levels
in SARS-CoV-infected Vero E6 cells. | en_US |
dc.language.iso | en | en_US |
dc.publisher | American Society for Microbiology | |
dc.rights | Copyright American Society for Microbiology. This file may be freely used for educational purposes, as long as it is not altered in any way. Acknowledgement of the authors and the source is required. | |
dc.source.uri | http://dx.doi.org/10.1128/JVI.79.15.10083-10087.2005 | |
dc.title | The Severe Acute Respiratory Syndrome Coronavirus 3a Protein Up-Regulates Expression of Fibrinogen in Lung Epithelial Cells | en_US |
dc.type | Article | en_US |
dc.privacy.showsubmitter | false | |
dc.status.ispeerreviewed | true | |
dc.description.accreditation | Web of Science | en_US |