Browsing Faculty of Natural Sciences by Author "Gamieldien, Junaid"
Now showing items 1-16 of 16
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A 35-gene signature discriminates between rapidly- and slowly-progressing glioblastoma multiforme and predicts survival in known subtypes of the cancer
Fatai, Azeez A.; Gamieldien, Junaid (BioMed Central, 2018)BACKGROUND: Gene expression can be employed for the discovery of prognostic gene or multigene signatures cancer. In this study, we assessed the prognostic value of a 35-gene expression signature selected by pathway ... -
The African Coelecanth genome provides insights into tetrapod evolution
Christoffels, Alan; Hesse, Uljana; Gamieldien, Junaid; Panji, Sumir; Picone, Barbara; Van Heusden, Peter (Macmillan Publishers, 2013)The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of lobe-finned fish was thought to have become extinct 70 million years ago. The modern coelacanth looks remarkably similar to many of ... -
Application of anin silicoapproach identifies a genetic locus withinITGB2,and itsinteractions withHSPG2 and FGF9,to be associated with anterior cruciateligament rupture risk
Dlamini, Senanile B.; Saunders, Colleen J.; Gamieldien, Junaid (Taylor and Francis Group, 2023)We developed a Biomedical Knowledge Graph model that is phenotype and biological function-aware through integrating knowledge from multiple domains in a Neo4j, graph database. Allknown human genes were assessed through the ... -
Computational characterization of iron metabolism in the tsetse disease vector, glossina morsitans: Ire stem-loops
Dashti, Zahra Jalali Sefid; Gamieldien, Junaid; Christoffels, Alan (BMC, 2016)Iron metabolism and regulation is an indispensable part of species survival, most importantly for blood feeding insects. Iron regulatory proteins are central regulators of iron homeostasis, whose binding to iron response ... -
Defining the molecular signatures of Achilles tendinopathy and anterior cruciate ligament ruptures: A whole-exome sequencing approach
Gibbon, Andrea; Saunders, Colleen J.; Collins, Malcolm; Gamieldien, Junaid; September, Alison V. (Public Library of Science, 2018)Musculoskeletal soft tissue injuries are complex phenotypes with genetics being one of many proposed risk factors. Case-control association studies using the candidate gene approach have predominately been used to identify ... -
Exome sequencing identifies novel dysferlin mutation in a family with pauci-symptomatic heterozygous carriers
Jalali-Sefid-Dashti, Mahjoubeh; Nel, Melissa; Heckmann, Jeannine M.; Gamieldien, Junaid (Springer Nature, 2018)Background: We investigated a South African family of admixed ancestry in which the first generation (G1) developed insidious progressive distal to proximal weakness in their twenties, while their offspring (G2) experienced ... -
Exome sequencing identifies novel dysferlin mutation in a family with paucisymptomatic heterozygous carriers
Jalali-Sefid-Dashti, Mahjoubeh; Nel, Melissa; Heckmann, Jeannine M.; Gamieldien, Junaid (BioMed Central, 2018)BACKGROUND: We investigated a South African family of admixed ancestry in which the first generation (G1) developed insidious progressive distal to proximal weakness in their twenties, while their offspring (G2) experienced ... -
Human coronavirus OC43 3CL protease and the potential of ML188 as a broad-spectrum lead compound: Homology modelling and molecular dynamic studies
Berry, Michael; Fielding, Burtram; Gamieldien, Junaid (Springer Nature, 2015)The coronavirus 3 chymotrypsin-like protease (3CLpro) is a validated target in the design of potential anticoronavirus inhibitors. The high degree of homology within the protease’s active site and substrate conservation supports ... -
Identification of new respiratory viruses in the new millennium
Berry, Michael; Gamieldien, Junaid (MDPI, 2015)The rapid advancement of molecular tools in the past 15 years has allowed for the retrospective discovery of several new respiratory viruses as well as the characterization of novel emergent strains. The inability to ... -
Identification of novel prognostic markers of survival time in high-risk neuroblastoma using gene expression profiles
Giwa, Abdulazeez; Fatai, Azeez A.; Gamieldien, Junaid (Impact Journals, 2020)Neuroblastoma is the most common extracranial solid tumor in childhood. Patients in high-risk group often have poor outcomes with low survival rates despite several treatment options. This study aimed to identify a genetic ... -
Modelling human protein interaction networks as metric spaces has potential in disease research and drug target discovery
Fadhal, Emad; Mwambene, Eric C; Gamieldien, Junaid (BMC, 2014)We have recently shown by formally modelling human protein interaction networks (PINs) as metric spaces and classified proteins into zones based on their distance from the topological centre that hub proteins are primarily ... -
Potential broad spectrum inhibitors of the coronavirus 3CLpro: A virtual screening and structure-based drug design study
Berry, Michael; Fielding, Burtram C.; Gamieldien, Junaid (MDPI, 2015)Human coronaviruses represent a significant disease burden; however, there is currently no antiviral strategy to combat infection. The outbreak of severe acute respiratory syndrome (SARS) in 2003 and Middle East respiratory ... -
Protein interaction networks as metric spaces: A novel perspective on distribution of hubs
Fadhal, Emad; Gamieldien, Junaid; Mwambene, Eric C (BMC, 2014)In the post-genomic era, a central and overarching question in the analysis of protein-protein interaction networks continues to be whether biological characteristics and functions of proteins such as lethality, physiological ... -
Self-similarity of human protein interaction networks: a novel strategy of distinguishing proteins
Fadhal, Emad; Gamieldien, Junaid; Mwambene, Eric (2015)The successful determination of reliable protein interaction networks (PINs) in several species in the post-genomic era has hitherto facilitated the quest to understanding systems and structural properties of such networks. ... -
Semantic interrogation of a multi knowledge domain ontological model of tendinopathy identifies four strong candidate risk genes
Saunders, Colleen J.; Dashti, Mahjoubeh Jalali Sefid; Gamieldien, Junaid (Nature Research, 2016)Tendinopathy is a multifactorial syndrome characterised by tendon pain and thickening, and impaired performance during activity. Candidate gene association studies have identified genetic factors that contribute to ... -
Whole-genome sequencing for an enhanced understanding of genetic variation among South Africans
Choudhury, Ananyo; Christoffels, Alan; Gamieldien, Junaid; Sefid-Dashti, Mahjoubeh J. (Nature Publishing Group, 2017)The Southern African Human Genome Programme is a national initiative that aspires to unlock the unique genetic character of southern African populations for a better understanding of human genetic diversity. In this pilot ...