Browsing Faculty of Natural Sciences by Author "Isaacs, Darren"
Now showing items 1-2 of 2
-
Interaction analysis of statistically enriched mutations identified in Cameroon recombinant subtype CRF02_AG that can influence the development of Dolutegravir drug resistance mutations
Mikas, Sello Given; Isaacs, Darren; Chitongo, Rumbidzai (BMC, 2021)The Integrase (IN) strand transfer inhibitor (INSTI), Dolutegravir (DTG), has been given the green light to form part of first-line combination antiretroviral therapy (cART) by the World Health Organization (WHO). ... -
Structural comparison of diverse HIV-1 subtypes using molecular modelling and docking analyses of integrase inhibitors
Isaacs, Darren; Mikasi, Sello Given; Obasa, Adetayo Emmanuel (MPDI, 2020)The process of viral integration into the host genome is an essential step of the HIV-1 life cycle. The viral integrase (IN) enzyme catalyzes integration. IN is an ideal therapeutic enzyme targeted by several drugs; ...