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Transcriptomic profile of mycobacterium smegmatis in response to an imidazo[1,2-b][1,2,4,5]tetrazine reveals its possible impact on iron metabolism
(Frontiers Media, 2021)
Tuberculosis (TB), caused by the Mycobacterium tuberculosis complex bacteria, is
one of the most pressing health problems. The development of new drugs and
new therapeutic regimens effective against the pathogen is one ...
Computational approaches for the design of novel anticancer compounds based on pyrazolo[3,4-d]pyrimidine derivatives as trap1 inhibitor
(MPDI, 2021)
In the present in-silico study, various computational techniques were applied to determine
potent compounds against TRAP1 kinase. The pharmacophore hypothesis DHHRR_1 consists of
important features required for activity. ...