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HIV-1 diversity and the implementation of integrase strand-transfer inhibitors as part of combination antiretroviral therapy
(SAMA, 2020)
: The integrase (IN) strand-transfer inhibitor (InSTI)
dolutegravir (DTG) is now recommended by the World Health
Organization as part of salvage and/or first-line combination
antiretroviral therapy (cART).[1] DTG has a ...
Multistage antiplasmodial activity of hydroxyethylamine compounds,in vitroandin vivoevaluations
(Royal Society of Chemistry, 2020)
Malaria, a global threat to the human population, remains a challenge partly due to the fast-growing drug-resistant strains of Plasmodium species. New therapeutics acting against the pathogenic asexual and sexual stages, ...
Using a multiple-delivery-mode training approach to develop local capacity and infrastructure for advanced bioinformatics in Africa
(Public Library of Science, 2021)
With more microbiome studies being conducted by African-based research groups, there is an increasing demand for knowledge and skills in the design and analysis of microbiome studies and data. However, high-quality ...
Capacity building for whole genome sequencing of Mycobacterium tuberculosis and bioinformatics in high TB burden countries
(Oxford University Press, 2020)
Background
Whole-genome sequencing (WGS) is increasingly used for Mycobacterium tuberculosis (Mtb) research. Countries with the highest tuberculosis (TB) burden face important challenges to integrate WGS into surveillance ...
Hypertension in African populations: Review and computational insights
(MPDI, 2021)
Hypertension (HTN) is a persistent public health problem affecting approximately 1.3 billion
individuals globally. Treatment-resistant hypertension (TRH) is defined as high blood pressure (BP)
in a hypertensive patient ...
Indigenous African cereal crops can contribute to mitigation of the impact of climate change on food security
(Arid land institute, 2021)
Zea mays L. (maize) is one of the top three cultivated cereals globally, along with
wheat and rice. The United States, China, and Brazil are among the largest
producers of maize, producing approximately 79% of the world’s ...
Common bean as a potential crop for future food security: an overview of past, current and future contributions in genomics, transcriptomics, transgenics and proteomics
(Taylor & Francis Open Access, 2021)
Common bean is an important legume crop having high quality protein, micronutrients, vitamins
and antioxidants, which makes it a “grain of hope” for poor communities. Hence, a good number
of breeding activities have been ...
Factors influencing the awareness and adoption of borehole-garden permaculture in Malawi: Lessons for the promotion of sustainable practices
(MPDI, 2021)
Using wastewater accumulating around rural waterpoints to irrigate community gardens,
borehole-garden permaculture (BGP) presents a method of sustainable water management. BGP also
presents public health benefits through ...
Africa 3: A continental network model to enable the African fourth industrial revolution
(IEEE, 2020)
It is widely recognised that collaboration can help fast-track the development of countries
in Africa. Leveraging on the fourth industrial revolution, Africa can achieve accelerated development in
health care services, ...
Methylenetetrahydrofolate Reductase Polymorphism (rs1801133) and the Risk of Hypertension among African Populations: A Narrative Synthesis of Literature
(MDPI, 2022)
In this review, we have gathered and analyzed the available genetic evidence on the
association between the methylenetetrahydrofolate reductase gene (MTHFR), rs1801133 and the
risk of Hypertension (HTN) in African ...