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Human coronavirus OC43 3CL protease and the potential of ML188 as a broad-spectrum lead compound: Homology modelling and molecular dynamic studies
(Springer Nature, 2015)
The coronavirus 3 chymotrypsin-like protease (3CLpro) is a validated target in the design of potential
anticoronavirus inhibitors. The high degree of homology within the protease’s active site and substrate conservation
supports ...
Modelling human protein interaction networks as metric spaces has potential in disease research and drug target discovery
(BMC, 2014)
We have recently shown by formally modelling human protein interaction networks (PINs) as metric
spaces and classified proteins into zones based on their distance from the topological centre that hub proteins are
primarily ...
Functional prediction of candidate micrornas for CRC management using in silico approach
(MDPI, 2019)
Approximately 30–50% of malignant growths can be prevented by avoiding risk factors
and implementing evidence-based strategies. Colorectal cancer (CRC) accounted for the second most
common cancer and the third most common ...
Is human immunodeficiency virus (HIV) stage an independent risk factor for altering the periodontal status of HIV-positive patients? A South African study
(BMC, 2013)
The immunosuppresion in HIV patients makes them highly susceptible to microbial infections. The
aim of the study was to establish whether HIV stage (as depicted by CD4+ T lymphocyte counts) could
independently be associated ...
Optimal strategy for controlling the spread of HIV/AIDS disease: A case study of South Africa
(Taylor and Francis Group, 2012)
HIV/AIDS disease continues to spread alarmingly despite the huge amounts of resources invested infighting it. There is a need to integrate the series of control measures available to ensure a consistentreduction ...
Correlates of gender characteristics, health and empowerment of women in Ethiopia
(BMC, 2015)
The low status of women prevents them from recognizing and voicing their concerns about health
needs. This study aimed to examine the relationship between gender characteristics, health and empowerment of
women in an ...
Exploring practising pharmacy graduates’ views on improving the effectiveness of pharmacy education at the University of the Western Cape, South Africa
(HEALTH & MEDICAL PUBLISHING GROUP, 2019)
South African health professional education institutions have a mandate to produce graduates who are able to address priority needs of the
healthcare system and larger society. However, evidence of the effective use of ...
Human coronavirus NL63: A clinically important virus?
(Future Science Group, 2011)
Respiratory tract infection is a leading cause of morbidity and mortality worldwide, especially among young children. Human coronaviruses (HCoVs) have only recently been shown to cause both lower and upper respiratory tract ...
Amount of cycloserine emanating from terizidone metabolism and relationship with hepatic function in patients with drug resistant tuberculosis
(Springer, 2019)
The dosing of cycloserine and terizidone is the same, as both drugs are considered equivalent
or used interchangeably. Nevertheless, it is not certain from the literature that these drugs are interchangeable. Therefore,
the ...
A weighted bootstrap approach to logistic regression modelling in identifying risk behaviours associated with sexual activity
(Taylor and Francis Group, 2019)
The latest population estimates released by Statistics South Africa indicate that 25.03% of alldeaths in 2017 in South Africa were AIDS-related. Along with these results, it is also reportedthat 7.06% of the population ...