Browsing School of Pharmacy by Title
Now showing items 86-105 of 151
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Marburg virus disease amid Covid-19 in West Africa: An emerging and re-emerging zoonotic epidemic threat, future implications and way forward
(2023)Amid the coronavirus 2019 (COVID-19) pandemic, several African countries including Ghana and Equatorial Guinea have reported several zoonotic outbreaks. The COVID-19 pandemic has added more strain on the already ... -
Marburg virus disease outbreak amidst COVID-19 in the Republic of Guinea: A point of contention for the fragile health system?
(Elsevier, 2022)In August 2021, the Marburg virus disease (MVD) outbreak was confirmed amid the coronavirus disease 2019 (COVID-19) pandemic in the Republic of Guinea. This is the first time it is detected in Guinea and West Africa. Marburg ... -
Mechanochemical synthesis and physicochemical characterization of isoniazid and pyrazinamide co-crystals with Glutaric acid
(Frontiers Media S.A., 2020)The present work reports two novel pharmaceutical co-crystals; 2:1 isoniazid-glutaric acid (INHGA) and 2:1 pyrazinamide-glutaric acid (PGA). Isoniazid and pyrazinamide are key first-line drugs used for the treatment of ... -
Medicine Runners: A community-initiated solution to chronic medicine access in underserved communities
(Medpharm, 2018)Patient access to chronic medicines is crucial in optimising disease management. With the introduction of a decentralised chronic dispensing unit, stable patients qualify to have access to their chronic medicines away ... -
Medicines regulatory science expertise in Africa: workforce capacity development and harmonisation activities towards the establishment of the African medicines agency
(Adis, 2022)The medicines regulatory landscape in Africa is undergoing transformation with at least two countries having National Medicines Regulatory Authorities (NRAs) that operate at World Health Organization (WHO) maturity level ... -
Meningitis during COVID -19 pandemic in the Democratic Republic of Congo: A call for concern
(Elsevier, 2022-01-01)Meningitis is a severe infection and a significant public health challenge. The meningitis outbreak resurfaced amid the coronavirus disease 2019 (COVID-19) pandemic in the Democratic Republic of Congo (DRC). The outbreak ... -
Microwave-assisted methods for the synthesis of pentacyclo[5.4.0.02,6.03,10.05,9]undecylamines
(Elsevier, 2013)Efficient methodologies for the preparation of pentacyclo[5..4.0.02,6.03,10.05,9]undecane (PCU) amine derivatives are described via microwave-assisted synthesis. The obtained results revealed that microwave-assisted synthetic ... -
Monkeypox during Covid-19 era in Africa: Current challenges and recommendations
(Elsevier, 2022)In May 2022, monkeypox virus (MPXV) outbreak was confirmed amid the coronavirus disease 2019 (COVID-19) pandemic in many parts of the world including Africa. This is the largest outbreak since monkeypox (MPX) was first ... -
Multi-targeted directed ligands for Alzheimer’s disease: design of novel lead coumarin conjugates
(Taylor & Francis, 2018)Alzheimer’s Disease (AD) is a neurodegenerative disease characterized by central nervous system insults with progressive cognitive (memory, attention) and non-cognitive (anxiety, depression) impairments. Pathophysiological ... -
Nanomedicines for infectious diseases
(Springer Nature, 2019)Infectious diseases continue to pose a significant threat to global health. Over 200 infectious diseases are currently known to man. Fortunately, only a handful are responsible for significant morbidity and mortality. ... -
Nevirapine plasma concentrations in premature infants exposed to single-dose nevirapine for prevention of mother-tochild transmission of HIV-1
(Health and Medical Publishing Group, 2011)Background: No pharmacokinetic data exist for premature infants receiving single-dose nevirapine (sd NVP) for prevention of mother-to-child transmission (MTCT) of HIV. Aim: To describe NVP decay pharmacokinetics in two ... -
New palladium (II) complexes from halogen substituted Schiff base ligands: Synthesis, spectroscopic, biological activity, density functional theory, and molecular docking investigations
(Inorganica Chimica Acta, 2023)Two novel palladium (II) complexes Pd(L1)2 and Pd(L2)2 derived from ON donor bidentate ligands: 2-(((2-bromo-4-chlorophenyl)imino)methyl)phenol (HL1) and 2-(((-bromo-4-methylphenyl)imino)methyl)phenol (HL2) are reported. ... -
Novel South African rare actinomycete kribbella speibonae Strain SK5: A prolific producer of hydroxamate siderophores including new dehydroxylated congeners
(MDPI, 2020)In this paper, we report on the chemistry of the rare South African Actinomycete Kribbella speibonae strain SK5, a prolific producer of hydroxamate siderophores and their congeners. Two new analogues, dehydroxylated ... -
Parental reporting of adverse drug reactions in South Africa: An online survey
(AOSIS, 2021)The high incidence of adverse drug reactions (ADRs) in children is of global concern. Enhancing the reporting of ADRs could contribute to making safer medicines available to children.To assess parents’ awareness of ... -
Patient with Kaposi’s Sarcoma: Teaching students medicine management therapy
(Medpharm, 2018)Interprofessional education (IPE) is a cornerstone in advancing health professional education, with the aim of improving the overall quality of healthcare.1 The World Health Organization (WHO) states: “Interprofessional ... -
Pharmaceutical co-crystal: An alternative strategy for enhanced physicochemical properties and drug synergy
(Wiley Open Access, 2020)A growing number of co-crystals in the literature are proof of how significant the co-crystallization concept has become. Co-crystallization enhances physicochemical properties through the formation of intermolecular ... -
A pharmacist-led prospective antibiotic stewardship intervention improves compliance to community-acquired pneumonia guidelines in 39 public and private hospitals across South Africa
(Elsevier, 2020)Introduction: Pharmacists in low-middle-income countries (LMIC) are few and lack antibiotic stewardship (AS) training. The ability was assessed of non-specialised pharmacists to implement stewardship interventions and ... -
Pharmacists’ approach to optimise safe medication use in paediatric patients
(MPDI, 2021)Paediatric patients are unique, yet challenging patients to care for by pharmacists. Paediatric medicine use requires special consideration. Pharmacists play an important role in educating and counselling patients, carers, ... -
Pharmacokinetics of vancomycin in critically Ill children: A systematic review
(European journal of drug metabolism and pharmacokinetics, 2021)Background and Objective Vancomycin is often used in the ICU for the treatment of Gram-positive bacterial infection. In critically ill children, there are pathophysiologic changes that afect the pharmacokinetics of vancomycin. ... -
Physicochemical stability of enriched phenolic fractions of cyclopia genistoides and ex vivo bi-directional permeability of major xanthones and benzophenones
(Georg Thieme Verlag, 2021)Fractions of an ultrafiltered Cyclopia genistoides extract, respectively enriched in xanthones and benzophenones, were previously shown to inhibit mammalian α -glucosidase in vitro. The present study investigated ex vivo ...