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Crataegus monogyna and centella asiatica extracts as inhibitors of cathepsin s
(Horizon Research Publishing, 2022)
Cathepsin cysteine proteases such as
cathepsin S are responsible for the unfavorable and
irreversible dysregulation of extracellular matrix (ECM)
proteolysis found in cardiomyopathy, heart valve diseases
and atherosclerosis. ...
Bioprospecting of Helichrysum species: Chemical profile, phytochemical properties, and antifungal efficacy against botrytis cinerea
(MDPI, 2023)
Variation in plant species and extraction solvents play a crucial role in the recovery of
their bioactive compounds and antifungal efficacy. Thus, in this study, a comparative investigation
was carried out using extraction ...
In-silico and in-vivo evaluation of the cardiovascular effects of five Leonotis leonurus diterpenes
(Obikeze, K. et al. (2023). In-silico and in-vivo evaluation of the cardiovascular effects of five Leonotis leonurus diterpenes. Scientific African, 19, e01510. 10.1016/j.sciaf.2022.e01510, 2023)
Leonotis leonurus extracts and compounds have been extensively studied for pharmacological effects. However, most of the diterpenes isolated from the plant have not been evaluated as possible contributors to the cardiovascular ...
Proprotein convertase subtilisin/kexin type 9 genetic screening using the vervet (Chlorocebus aethiops) model
(Journal of Medical Primatology, 2022)
Background: The proprotein convertase subtilisin/kexin type 9 (PCSK9) gene has come to prominence due to its reported function in the clearance of low-density li-poprotein cholesterol. The vervet monkey (Chlorocebus ...