Research Articles (School of Pharmacy): Recent submissions
Now showing items 41-60 of 151
-
Synthesis, Crystal Structure, DFT Studies, Docking Studies, and Fluorescent Properties of 2-(Adamantan-1-yl)-2H-isoindole-1-carbonitrile
(MDPI, 2019)2-(Adamantan-1-yl)-2H-isoindole-1-carbonitrile (1) has been identified as a neurobiological fluorescent ligand that may be used to develop receptor and enzyme binding affinity assays. Compound 1 was synthesized using an ... -
Time trends in Tuberculosis mortality across the BRICS: An age-period-cohort analysis for the GBD 2019
(Elsevier, 2022)There were 549,522 tuberculosis deaths across the BRICS in 2019, accounting for 39.3% of global deaths. Among HIV-negative populations, the age-standardised mortality rate (ASMR) of tuberculosis in BRICS remained far ... -
Inequalities in the prevalence of stunting, anemia and exclusive breastfeeding among African children
(BMC, 2022)Childhood stunting and anemia are on the increase in many resource-constrained settings, without a counter increase in proper feeding practices such as exclusive breastfeeding. The objective of this study was to explore ... -
Pharmacokinetics of vancomycin in critically Ill children: A systematic review
(European journal of drug metabolism and pharmacokinetics, 2021)Background and Objective Vancomycin is often used in the ICU for the treatment of Gram-positive bacterial infection. In critically ill children, there are pathophysiologic changes that afect the pharmacokinetics of vancomycin. ... -
Crataegus monogyna and centella asiatica extracts as inhibitors of cathepsin s
(Horizon Research Publishing, 2022)Cathepsin cysteine proteases such as cathepsin S are responsible for the unfavorable and irreversible dysregulation of extracellular matrix (ECM) proteolysis found in cardiomyopathy, heart valve diseases and atherosclerosis. ... -
Common Deficiencies Found in the Active Pharmaceutical Ingredient (API) Section of Non-sterile Generic Products Submitted for Registration by SAHPRA
(Springer Science and Business Media Deutschland GmbH, 2023)Purpose: This research study aims to determine the qualitative and quantitative common deficiencies included in the API section of dossiers submitted to SAHPRA. The study was conducted retrospectively over a 7-year period ... -
In vitro alpha-glucosidase and alpha-amylase inhibitory activities and antioxidant capacity of helichrysum cymosum and helichrysum pandurifolium schrank constituents
(MDPI, 2022)Diabetes mellitus (DM) is a group of systemic metabolic disorders with a high rate of morbidity and mortality worldwide. Due to the detrimental side effects of the current treatment, there is a great need to develop more ... -
Monkeypox during Covid-19 era in Africa: Current challenges and recommendations
(Elsevier, 2022)In May 2022, monkeypox virus (MPXV) outbreak was confirmed amid the coronavirus disease 2019 (COVID-19) pandemic in many parts of the world including Africa. This is the largest outbreak since monkeypox (MPX) was first ... -
Fractions of Hoslundia opposita Vahl and hoslundin induced apoptosis in human cancer cells via mitochondrial-dependent reactive oxygen species (ROS) generation
(Elsevier, 2022)ancer remains one of the leading causalities of several morbidity and mortality with negative impact on global economy due to low workforce and management/treatment cost. A number of conventional therapies have been ... -
Zebrafish behavioral response to ivermectin: Insights into potential neurological risk
(Elsevier, 2022)Ivermectin is a well‐known and widely used anti‐parasitic drug. Recently, in vitro data suggest anti‐viral effi- cacy of the drug, albeit at much higher concentrations than currently approved. Despite warnings by ... -
Insights into innovative therapeutics for drug-resistant tuberculosis: Host-directed therapy and autophagy inducing modified nanoparticles
(Elsevier, 2022)Tuberculosis (TB) remains one of the deadliest communicable dis- eases caused by Mycobacterium tuberculosis (Mtb) since its discovery in the 1880s (Cambau and Drancourt, 2014; Singh et al., 2020). Over 1 billion mortalities ... -
Association between socio-economic factors and HIV self-testing knowledge amongst South African women
(AOSIS, 2022)Self-testing for HIV is an effective and alternative method of increasing HIV testing rates and a strategy for reaching populations that are underserved by HIV testing services. Nonetheless, many resource-constrained ... -
Crystal engineering and thin-film deposition strategies towards improving the performance of kesterite photovoltaic cell
(Elsevier, 2021)With high absorption coefficient (104 cm 1), optimal bandgap (~1.5 eV), low toxicity and the abundance of its constituent elements, kesterite (Cu2ZnSnS4 or CZTS) displays the properties of an ideal photovoltaic material. ... -
Comparative evaluation of pharmacy students’ knowledge and skills in maternal and child health: Traditional versus integrated curriculum
(MDPI, 2022): Reducing maternal and child mortality is a health priority in South Africa. Therefore, health professional education should produce graduates that can meet these needs. This study compared the maternal and child health ... -
Establishing a pharmacist–prescriber partnership in publicly funded primary healthcare clinics to optimise antibiotic prescribing in the Western Cape: An exploratory study
(AOSIS, 2020)Promoting evidence-based antibiotic prescribing through successful antimicrobial stewardship (AMS) programmes is critical to preserving the effectiveness of antibiotics for common infections in primary care. This requires ... -
Continuous professional development for public sector pharmacists in South Africa: A case study of mapping competencies in a pharmacists’ preceptor programme
(MPDI, 2020)Lifelong learning among healthcare practitioners is crucial to keep abreast of advances in therapeutic and service delivery approaches. In South Africa, continuous professional development (CPD) was mandated (2019) for ... -
Pharmacists’ approach to optimise safe medication use in paediatric patients
(MPDI, 2021)Paediatric patients are unique, yet challenging patients to care for by pharmacists. Paediatric medicine use requires special consideration. Pharmacists play an important role in educating and counselling patients, carers, ... -
Medicines regulatory science expertise in Africa: workforce capacity development and harmonisation activities towards the establishment of the African medicines agency
(Adis, 2022)The medicines regulatory landscape in Africa is undergoing transformation with at least two countries having National Medicines Regulatory Authorities (NRAs) that operate at World Health Organization (WHO) maturity level ... -
Parental reporting of adverse drug reactions in South Africa: An online survey
(AOSIS, 2021)The high incidence of adverse drug reactions (ADRs) in children is of global concern. Enhancing the reporting of ADRs could contribute to making safer medicines available to children.To assess parents’ awareness of ... -
Venous thromboembolism risk assessment and prophylaxis in hospitalised medical patients in the Cape Town metropole, South Africa
(South African Medical Association, 2022)Venous thromboembolism (VTE) is regarded as the most preventable cause of inpatient death in hospital settings globally. VTE can be prevented through the provision of non-pharmacological and/or pharmacological thromboprophylaxis ...