Browsing Biotechnology by Author "Bakare, Olalekan Olanrewaju"
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Analytical studies of antimicrobial peptides as diagnostic biomarkers for the detection of bacterial and viral Pneumonia
Bakare, Olalekan Olanrewaju; Gokul, Arun; Keyster, Marshall (MDPI, 2022)Pneumonia remains one of the leading causes of infectious mortality and significant economic losses among our growing population. The lack of specific biomarkers for correct and timely diagnosis to detect patients’ status ... -
Building HMM and molecular docking analysis for the sensitive detection of anti-viral pneumonia antimicrobial peptides (AMPs)
Bakare, Olalekan Olanrewaju; Keyster, Marshall; Pretorius, Ashley (Nature Research, 2021)Pneumonia is the main reason for mortality among children under five years, causing 1.6 million deaths every year; late research has exhibited that mortality is increasing in the elderly. A few biomarkers used for its ... -
Diagnostic approaches of pneumonia for commercial-scale biomedical applications: An overview
Bakare, Olalekan Olanrewaju; Fadaka, Adewale Oluwaseun; Klein, Ashwil (Taylor & Francis, 2020)Pneumonia remains the leading infectious cause of death among children under five years of age, and the elderly. Several biomarkers, which have been identified for its diagnosis lack specificity, as they could not ... -
Dietary effects of antimicrobial peptides in therapeutics
Bakare, Olalekan Olanrewaju; Fadaka, Adewale Oluwaseun; Klein, Ashwil; Pretorius, Ashley (Taylor & Francis, 2020-02-17)The notable increase in drug-resistant infections and the failure of the most potent antibiotics to establish their curative effect without side effect have presented a serious need for the discovery of new therapeutic ... -
Gene expression alterations and molecular analysis of CHEK1 in solid tumors
Fadaka, Adewale Oluwaseun; Bakare, Olalekan Olanrewaju; Sibuyi, Nicole Remaliah Samantha (MDPI, 2020)Alterations in the Checkpoint kinase (CHEK1) gene, its regulation, and the possible clinical outcomes in human solid tumors have not been previously examined. Therefore, the present study was carried out to evaluate the ... -
Identification of biomarkers for the accurate and sensitive diagnosis of three bacterial pneumonia pathogens using in silico approaches
Bakare, Olalekan Olanrewaju; Keyster, Marshall; Pretorius, Ashley (Springer Nature, 2020): Pneumonia ranks as one of the main infectious sources of mortality among kids under 5 years of age, killing 2500 a day; late research has additionally demonstrated that mortality is higher in the elderly. A few ... -
Plant antimicrobial peptides (pamps): Features, applications, production, expression and challenges
Bakare, Olalekan Olanrewaju; Gokul, Arun; Fadaka, Adewale Oluwaseun (MDPI, 2022)The quest for an extraordinary array of defense strategies is imperative to reduce the challenges of microbial attacks on plants and animals. Plant antimicrobial peptides (PAMPs) are a subset of antimicrobial peptides ... -
PR-1-Like Protein as a Potential Target for the Identification of Fusarium oxysporum: An In Silico Approach
Bakare, Olalekan Olanrewaju; Gokul, Arun; Keyser, Marshall (BioTech, 2021-07)Fusarium oxysporum remains one of the leading causes of economic losses and poor crop yields; its detection is strained due to its presentation in various morphological and physiological forms. This research work sought ... -
The Relationship between Cadmium Toxicity and the Modulation of Epigenetic Traits in Plants
Niekerk, Lee- Ann; Bakare, Olalekan Olanrewaju; Carelse, Mogamat Fahiem; Keyser, Marshall; Mavumengwana, Vuyo; Gokul, Arun (International Journal of Molecular Sciences, 2021-06)Elevated concentrations of heavy metals such as cadmium (Cd) have a negative impact on staple crop production due to their ability to elicit cytotoxic and genotoxic effects on plants. In order to understand the relationship ...