4-Oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione Derivatives as NMDA Receptor- and VGCC Blockers with Neuroprotective Potential
Abstract
The impact of excitotoxicity mediated by N-methyl-D-aspartate (NMDA) receptor
overactivation and voltage gated calcium channel (VGCC) depolarization is prominent among
the postulated processes involved in the development of neurodegenerative disorders. NGP1-01,
a polycyclic amine, has been shown to be neuroprotective through modulation of the NMDA
receptor and VGCC, and attenuation of MPP+-induced neurotoxicity. Recently, we reported on
the calcium modulating effects of tricycloundecene derivatives, structurally similar to NGP1-01,
on the NMDA receptor and VGCC of synaptoneurosomes.