Medical Bioscience
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The department fields specific expertise within the broad research fields of Anatomy, Cardiovascular Physiology, Herbal Sciences, Immunology, Medical Microbiology, Molecular & Cell Biology, Neuroscience, Reproduction, Toxicology and Virology
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A new fluorescent method to determine honey bee sperm motility parameters with computer-aided sperm analysis
(Taylor and Francis Ltd., 2023)Honey bees are a keystone species, playing an important role in the food cycle. Improving honey bee reproduction will aid in the replacement of lost colonies. Fertility potential and reproductive health are dependent on ... -
Black tea aqueous extracts improve human sperm functions: an in vitro study
(Wiley-Hindawi, 2023)Infertility affects about 25% of couples worldwide, and oxidative stress (OS) is linked to its idiopathic etiology. Green, black, white, and oolong teas are produced from Camellia sinensis, depending on their oxidation ... -
Improving productivity and soil fertility in Medicago sativa and Hordeum marinum through intercropping under saline conditions
(BioMed Central Ltd, 2024)Background and aims: Intercropping is an agriculture system used to enhance the efficiency of resource utilization and maximize crop yield grown under environmental stress such as salinity. Nevertheless, the impact of ... -
Histomorphometric changes in testis following administration of tenofovir nanoparticles in an animal model
(Springer, 2024)Background: Nanoparticle-based drugs are new inventions in the management of the Human immunodeficiency virus (HIV) pandemic, especially resistant forms of the virus in anatomical sanctuary sites and organs such as the ... -
Aqueous extractions of mondia whitei root improve human sperm function in vitro
(Elsevier B.V., 2024)Introduction: Mondia whitei (Mw) is a prominent African medicinal plant that is widely used as traditional treatment in the management of sexual dysfunction and male infertility. Yet, there is a paucity of scientific ... -
Frequency, kinetics and determinants of viable SARS-cov-2 in bioaerosols from ambulatory COVID-19 patients infected with the beta, delta or omicron variants
(Nature Research, 2024)Airborne transmission of SARS-CoV-2 aerosol remains contentious. Importantly, whether cough or breath-generated bioaerosols can harbor viable and replicating virus remains largely unclarified. We performed size-fractionated ... -
Antioxidant, anti-diabetic, and anti-inflammation activity of Garcinia livingstonei aqueous leaf extract: a preliminary study
(Multidisciplinary Digital Publishing Institute (MDPI), 2024)Diabetes mellitus (DM) is the second leading cause of mortality globally. The increased concern for DM is due to the underlying complications accompanying hyperglycaemia, associated with oxidative stress and consequent ... -
Green synthesis of gold nanoparticles using liquiritin and other phenolics from Glycyrrhiza glabra and their anti-Inflammatory activity
(Multidisciplinary Digital Publishing Institute (MDPI), 2024)Phenolic compounds are the main phytochemical constituents of many higher plants. They play an important role in synthesizing metal nanoparticles using green technology due to their ability to reduce metal salts and stabilize ... -
In vitro neuroprotective effects of boophone disticha, brunsvigia bosmaniae and strumaria truncata extracts in SH-SY5Y cells
(Elsevier B.V., 2024)Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease. The pathological hallmarks of PD are defined by the loss of dopaminergic neurons in the substantia nigra pars compacta ... -
The impact of mitochondrial impairments on sperm function and male fertility: a systematic revie
(BMC, 2024)Background Besides adenine triphosphate (ATP) production for sustaining motility, the mitochondria of sperm also host other critical cellular functions during germ cell development and fertilization including calcium ... -
Biosensors as early warning detection systems for waterborne cryptosporidium
(IWA Publishing, 2023)Waterborne disease is a global health threat contributing to a high burden of diarrhoeal disease, and growing evidence indicates a prospective increase in incidence coinciding with the profound effects of climate change. ... -
The impact of mitochondrial impairments on sperm function and male fertility: a systematic review
(University of the Western Cape, 2024)Background Besides adenine triphosphate (ATP) production for sustaining motility, the mitochondria of sperm also host other critical cellular functions during germ cell development and fertilization including calcium ... -
Evaluation of synergistic anticandidal activity of galenia africana extract and fluconazole against candida albicans and candida glabrata
(Elsevier, 2022-03)Candida infections have increased in recent years and are causing a serious public health concern. In addition, Candida species are becoming resistant to numerous antifungal drugs. It is for this reason that alternative ... -
Overview of the effects of moringa oleifera leaf extract on oxidative stress and male infertility: a review
(MDPI, 2023)According to a recent report by the WHO, 50–80 million people suffer with infertility. Amongst these populations, male counterparts account for 20–50% of infertility cases. The aetiology of infertility in men includes many ... -
Controversy and consensus on indications for sperm dna fragmentation testing in male infertility: a global survey, current guidelines, and expert recommendations
(Korean Society for Sexual Medicine and Andrology, 2023)Purpose: Sperm DNA fragmentation (SDF) testing was recently added to the sixth edition of the World Health Organization laboratory manual for the examination and processing of human semen. Many conditions and risk factors ... -
The pathophysiology of rhabdomyolysis in ungulates and rats: towards the development of a rodent model of capture myopathy
(Springer, 2023)Capture myopathy (CM), which is associated with the capture and translocation of wildlife, is a life-threatening condition that causes noteworthy morbidity and mortality in captured animals. Such wildlife deaths have a ... -
Microplastic sources, formation, toxicity and remediation: A review
(Springer, 2023)Microplastic pollution is becoming a major issue for human health due to the recent discovery of microplastics in most ecosystems. Here, we review the sources, formation, occurrence, toxicity and remediation methods of ... -
Effects of temperature and storage time on the motility, viability, DNA integrity and apoptosis of processed human spermatozoa
(Wiley, 2019)The aim of this study was to evaluate motility, viability, DNA integrity and apoptosis of spermatozoa when washed semen samples were kept for up to 12 days at 4–6°C and 25°C. In this experimental study, 26 normozoospermic ... -
Critical evaluation of two models of flow cytometers for the assessment of sperm DNA fragmentation: an appeal for performance verification
(Medknow Publications, 2019)Lack of standardized, reproducible protocols and reference values is among the challenges faced when using new or upgraded versions of instruments in reproductive laboratories and flow cytometry. Terminal deoxynucleotidyl ... -
Autoimmune progesterone dermatitis: Case report with history of urticaria, petechiae and palpable pinpoint purpura triggered by medical abortion
(South African Medical Association, 2016)Autoimmune progesterone dermatitis (APD) is a rare autoimmune response to raised endogenous progesterone levels that occur during the luteal phase of the menstrual cycle. Cutaneous, mucosal lesions and other systemic ...
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