Browsing South African National Bioinformatics Institute (SANBI) by Author "Grant, Oliver C."
Now showing items 1-2 of 2
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The Influence of N-Linked Glycans on the MolecularDynamics of the HIV-1 gp120 V3 Loop
Wood, Natasha T.; Fadda, Elisa; Davis, Robert; Grant, Oliver C.; Martin, Joanne C.; Woods, Robert J.; Travers, Simon A. (PLoS ONE, 2013)N-linked glycans attached to specific amino acids of the gp120 envelope trimer of a HIV virion can modulate the binding affinity of gp120 to CD4, influence coreceptor tropism, and play an important role in neutralising ... -
Structural rearrangements maintain the Glycan Shield of an HIV-1 envelope trimer after the loss of a glycan
Ferreira, Roux-Cil; Grant, Oliver C.; Moyo, Thandeka; Dorfman, Jeffrey R.; Woods, Robert J.; Travers, Simon A.; Wood, Natasha T. (Nature Research, 2018)The HIV-1 envelope (Env) glycoprotein is the primary target of the humoral immune response and a critical vaccine candidate. However, Env is densely glycosylated and thereby substantially protected from neutralisation. ...