Browsing Research Articles (SANBI) by Author "Christoffels, Alan"
Now showing items 21-35 of 35
-
In silico repurposing of a Novobiocin derivative for activity against latency associated Mycobacterium tuberculosis drug target nicotinate-nucleotide adenylyl transferase (Rv2421c)
Cloete, Ruben; Shahbaaz, Mohd; Christoffels, Alan (Public Library of Science, 2021)Nicotinamide-nucleotide adenylyl transferase (Rv2421c) was selected as a potential drug target, because it has been shown, in vitro, to be essential for Mycobacterium tuberculosis growth. It is conserved between mycobacterium ... -
Inferring bona fide transfrags in RNA-Seq derived-transcriptome assemblies of non-model organisms
Mbandi, Stanley K.; Hesse, Uljana; Van Heusden, Peter; Christoffels, Alan (BioMed Central, 2015)Background: De novo transcriptome assembly of short transcribed fragments (transfrags) produced from sequencing-by-synthesis technologies often results in redundant datasets with differing levels of unassembled, partially ... -
Information security at South African universities-Implications for biomedical research
Anderson, Dominique; Abiodun, Oluwafemi Peter; Christoffels, Alan (Oxford University Press, 2020)In South Africa, a similar regulation strategy to the European Union General Data Protection Regulation, called the Protection of Personal Information Act (No 4 of 2013) (POPIA), will be implemented, with a view to ... -
An integrated and comparative approach towards identification, characterization and functional annotation of candidate genes for drought tolerance in sorghum (Sorghum bicolor (L.) Moench)
Woldesemayat, Adugna Abdi; Van Heusden, Peter; Ndimba, Bongani K.; Christoffels, Alan (BioMed Central, 2017)BACKGROUND: Drought is the most disastrous abiotic stress that severely affects agricultural productivity worldwide. Understanding the biological basis of drought-regulated traits, requires identification and an in-depth ... -
International Glossina Genome Initiative 2004-2014: a driver for post-genomic era research on the African continent
Christoffels, Alan; Masiga, Daniel K.; Berriman, Matthew; Lehane, Mike; Toure', Yeya; Aksoy, Serap (PLOS, 2014)Human African trypanosomiasis (HAT), also known as sleeping sickness, is a neglected disease that impacts 70 million people distributed over 1.55 million km2 in sub- Saharan Africa and includes at least 50% of the population ... -
Investigation of distinct gene expression profile patterns that can improve the classification of intermediate-risk prognosis in AML patients
Eshibona, Nasr; Livesey, Michelle; Christoffels, Alan (Frontiers Media, 2023)Acute myeloid leukemia (AML) is a heterogeneous type of blood cancer that generally affects the elderly. AML patients are categorized with favorable-, intermediate-, and adverse-risks based on an individual’s genomic ... -
Mice and men: Their promoter properties
Bajic, Vladimir B.; Tan, Sin lam; Christoffels, Alan; Schonbach, Christian; Lipovich, Leonard; Yang, Liang; Hofmann, Oliver; Kruger, Adele; Hide, Winston; Kai, Chikatoshi; Kawai, Jun; Hume, David, A.; Carninci, Piero; Hayashizaki, Yoshihide (PLoS Genetics, 2006)Using the two largest collections of Mus musculus and Homo sapiens transcription start sites (TSSs) determined based on CAGE tags, ditags, full-length cDNAs, and other transcript data, we describe the compositional landscape ... -
Molecular evolution of key receptor genes in primates and non-human primates
Picone, Barbara; Christoffels, Alan (Science Publishing Group, 2014)African primates remain an unexplored source of information required to complete the origin and evolution of many human pathogens. Current studies have shown the importance of several receptor human genes implicated in ... -
Odorant and gustatory receptors in the tsetse fly Glossina morsitans morsitans
Obiero, George F.; Nyanjom, Steven R. G.; Mireji, Paul O.; Christoffels, Alan; Robertson, Hugh M.; Masiga, Daniel K. (PLOS, 2014)Tsetse flies use olfactory and gustatory responses, through odorant and gustatory receptors (ORs and GRs), to interact with their environment. Glossina morsitans morsitans genome ORs and GRs were annotated using homologs ... -
Prediction of human-Bacillus anthracis protein–protein interactions using multi-layer neural network
Ahmed, Ibrahim; Witbooi, Peter; Christoffels, Alan (Oxford University Press, 2018)Triplet amino acids have successfully been included in feature selection to predict human-HPV protein-protein interactions (PPI). The utility of supervised learning methods is curtailed due to experimental data not being ... -
Predictive classifier models built from natural products with antimalarial bioactivity using machine learning approach
Egieyeh, Samuel; Syce, James; Malan, Sarel F.; Christoffels, Alan (Public Library of Science, 2018)In view of the vast number of natural products with potential antiplasmodial bioactivity and cost of conducting antiplasmodial bioactivity assays, it may be judicious to learn from previous antiplasmodial bioassays and ... -
Structure based identification of novel inhibitors against ATP synthase of Mycobacterium tuberculosis: A combined in silico and in vitro study
Cloete, Ruben; Grobbelaar, Melanie; Sampson, Samantha; Christoffels, Alan (International Journal of Biological Macromolecules, 2019)The shortcomings of conventional tuberculosis treatments resulting from the development of drug resistance in Mycobacteriumtuberculosis drive a need for the formulation of novel therapeutic agents. The diarylquinoline ... -
Taste and odorant receptors of the coelecanth- a gene repertoire in transition
Picone, Barbara; Hesse, Uljana; Panji, Sumir; Van Heusden, Peter; Jonas, Mario; Christoffels, Alan (Wiley, 2014)G-protein coupled chemosensory receptors (GPCR-CRs) aid in the perception of odors and tastes in vertebrates. So far, six GPCR-CR families have been identified that are conserved in most vertebrate species. Phylogenetic ... -
Transcriptomic analysis reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain
Sreenivasan, Rajini; Cai, Minnie; Bartfai, Richard; Wang, Xingang; Orban, Laszlo; Christoffels, Alan (Plosone, 2008)Our knowledge on zebrafish reproduction is very limited. We generated a gonad-derived cDNA microarray from zebrafish and used it to analyze large-scale gene expression profiles in adult gonads and other organs. We have ... -
Whole-genome sequencing for an enhanced understanding of genetic variation among South Africans
Choudhury, Ananyo; Christoffels, Alan; Gamieldien, Junaid; Sefid-Dashti, Mahjoubeh J. (Nature Publishing Group, 2017)The Southern African Human Genome Programme is a national initiative that aspires to unlock the unique genetic character of southern African populations for a better understanding of human genetic diversity. In this pilot ...