Browsing Research Articles (SANBI) by Author "Shahbaaz, Mohd"
Now showing items 1-14 of 14
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Antennal enriched odorant binding proteins are required for odor communication in glossina f. Fuscipes
Diallo, Souleymane; Shahbaaz, Mohd; Makwatta, JohnMark O. (MPDI, 2021)Olfaction is orchestrated at different stages and involves various proteins at each step. For example, odorant-binding proteins (OBPs) are soluble proteins found in sensillum lymph that might encounter odorants before ... -
Carbonic anhydrase II based biosensing of carbon dioxide at high temperature: an analytical and MD simulation study
Idrees, Danish; Anwer, Razique; Shahbaaz, Mohd; Sabela, Myalowenkosi; Khamees, Osama A. Al; Gourinath, Samudrala; Kumar, Manoj; Singh, M.P.; Qumaizi, Khalid I. Al (OMICS International, 2018)Concentration of carbon dioxide (CO2) in the atmosphere has increased significantly due to anthropogenic activities and attributed as a major factor to global warming. Its detection by biosensing methods will provide ... -
Cellular and molecular targets of waterbuck repellent blend odors in antennae of glossina fuscipes fuscipes newstead, 1910
Diallo, Souleymane; Shahbaaz, Mohd; Torto, Baldwyn (Frontiers Media S.A., 2020)Insects that transmit many of the world’s deadliest animal diseases, for instance trypanosomosis, find their suitable hosts and avoid non-preferred hosts mostly through olfactory cues. The waterbuck repellent blend (WRB) ... -
Computational approaches for the design of novel anticancer compounds based on pyrazolo[3,4-d]pyrimidine derivatives as trap1 inhibitor
Ali, Amen; Abdellattif, Magda H; Shahbaaz, Mohd (MPDI, 2021)In the present in-silico study, various computational techniques were applied to determine potent compounds against TRAP1 kinase. The pharmacophore hypothesis DHHRR_1 consists of important features required for activity. ... -
Corrigendum: Synthesis and cytotoxic activity of novel indole derivatives and their in silico screening on spike glycoprotein of sars-cov-2
Gobinath, Perumal; Packialakshmi, Ponnusamy; Shahbaaz, Mohd (Frontiers Media, 2021)The authors Kaliappillai Vijayakumar, Magda H. Abdellattif, Mohd Shahbaaz were not included in the published article and the authors Daoud Ali, Saud Alarifi, and Amal Alotaibi were mistakenly included in the author list. ... -
Current perspectives in the discovery of newer medications against the outbreak of Covid-19
Ramesh, M.; Anand, Krishnan; Shahbaaz, Mohd (Frontiers Media, 2021)A rapid and increasing spread of COVID-19 pandemic disease has been perceived worldwide in 2020. The current COVID-19 disease outbreak is due to the spread of SARS-CoV-2. SARS-CoV-2 is a new strain of coronavirus that ... -
Designing novel possible kinase inhibitor derivatives as therapeutics against Mycobacterium tuberculosis: An in silico study
Shahbaaz, Mohd; Nkaule, Anati; Christoffels, Alan (Scientific Reports, 2019)Rv2984 is one of the polyphosphate kinases present in Mycobacterium tuberculosis involved in the catalytic synthesis of inorganic polyphosphate, which plays an essential role in bacterial virulence and drug resistance. ... -
Functional and structural analysis of predicted proteins obtained from homo sapiens' minisatellite 33.15-tagged transcript pAKT-45 variants
Shahbaaz, Mohd; Al-Samghan, Awad Saeed; Alzahrani, Othman Rashed (Hindawi, 2020)The spermatozoa are transcriptionally dormant entities which have been recognized to be an archive of mRNA, coding for a variety of functionally crucial cellular proteins. This significant repository of mRNA is predicted ... -
In silico repurposing of a Novobiocin derivative for activity against latency associated Mycobacterium tuberculosis drug target nicotinate-nucleotide adenylyl transferase (Rv2421c)
Cloete, Ruben; Shahbaaz, Mohd; Christoffels, Alan (Public Library of Science, 2021)Nicotinamide-nucleotide adenylyl transferase (Rv2421c) was selected as a potential drug target, because it has been shown, in vitro, to be essential for Mycobacterium tuberculosis growth. It is conserved between mycobacterium ... -
Inhibiting CDK6 activity by quercetin is an attractive strategy for cancer therapy
Shahbaaz, Mohd; Yousuf, Mohd; Khan, Parvez (American Chemical Society, 2020)Cyclin-dependent kinase 6 (CDK6) is a potential drug target that plays an important role in the progression of different types of cancers. We performed in silico and in vitro screening of different natural compounds and ... -
A novel nano therapeutic using convalescent plasma derived exosomal (CPExo) for Covid-19: A combined hyperactive immune modulation and diagnostics
Anand, Krishnan; Vadivalagan, Chithravel; Shahbaaz, Mohd (Elsevier, 2021)Extracellular vesicles like exosomes are important therapeutic tactics for treating COVID -19. By utilizing convalescent plasma derived exosomes (CPExo) from COVID-19 recovered persistence could accelerate the treatment ... -
Repurposing based identification of novel inhibitors against mmps5-mmpl5 efflux pump of Mycobacterium smegmatis: A combined in silico and in vitro study
Shahbaaz, Mohd; Maslov, Dmitry A.; Vatlin, Aleksey A. (MDPI, 2022)In the current era of a pandemic, infections of COVID-19 and Tuberculosis (TB) enhance the detrimental effects of both diseases in suffering individuals. The resistance mechanisms evolving in Mycobacterium tuberculosis ... -
Synthesis of oxygen deficient tio2 for improved photocatalytic efficiency in solar radiation
Badmus, Kassim Olasunkanmi; Wewers, Francois; Shahbaaz, Mohd (MDPI, 2021)The photocatalytic activities of TiO2 have been limited mainly to absorbing in the ultraviolet spectrum which accounts for only 5% of solar radiation. High energy band gap and electron recombination in TiO2 nanoparticles ... -
Transcriptomic profile of mycobacterium smegmatis in response to an imidazo[1,2-b][1,2,4,5]tetrazine reveals its possible impact on iron metabolism
Vatlin, Aleksey A.; Shitikov, Egor A.; Shahbaaz, Mohd (Frontiers Media, 2021)Tuberculosis (TB), caused by the Mycobacterium tuberculosis complex bacteria, is one of the most pressing health problems. The development of new drugs and new therapeutic regimens effective against the pathogen is one ...