dc.contributor.author | Naki, Tobeka | |
dc.contributor.author | Egieyeh, Samuel Ayodele | |
dc.contributor.author | Matshe, William Morwa Reagile | |
dc.date.accessioned | 2024-07-29T08:01:32Z | |
dc.date.available | 2024-07-29T08:01:32Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Naki, T., Matshe, W.M.R., Balogun, M.O., Sinha Ray, S., Egieyeh, S.A. and Aderibigbe, B.A., 2023. Polymer drug conjugates containing memantine, tacrine and cinnamic acid: promising nanotherapeutics for the treatment of Alzheimer’s disease. Journal of Microencapsulation, 40(1), pp.15-28. | en_US |
dc.identifier.issn | 02652048 | |
dc.identifier.issn | uri:http://doi.org/10.1080/02652048.2023.2167011 | |
dc.identifier.uri | http://hdl.handle.net/10566/9364 | |
dc.description.abstract | Aim: To prepare polymer-drug conjugates containing a combination of memantine, tacrine, and E)-N-(3-aminopropyl)cinnamide, promising therapeutics for the treatment of neurodegenerative disorders. Methods: The conjugates were characterised by 1HNMR, particle size analysis, SEM, LC-MS, TEM/EDX, and XRD, followed by in vitro anti-acetylcholinesterase and drug release studies. Results: 1H NMR analysis revealed successful drug conjugation with drug mass percentages in the range of 1.3–6.0% w/w. The drug release from the conjugates was sustained for 10 h in the range of 20–36%. The conjugates’ capability to inhibit acetylcholinesterase (AChE) activity was significant with IC50 values in the range of 13–44.4 µm which was more effective than tacrine (IC50 =1698.8 µm). The docking studies further confirmed that the conjugation of the drugs into the polymer improved their anti-acetylcholinesterase activity. Conclusion: The drug release profile, particle sizes, and in vitro studies revealed that the conjugates are promising therapeutics for treating neurodegenerative disorders. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Taylor and Francis Ltd. | en_US |
dc.subject | Alzheimer’s disease | en_US |
dc.subject | cinnamic acid | en_US |
dc.subject | memantine | en_US |
dc.subject | polyamidoamine | en_US |
dc.subject | polymer-drug conjugate | en_US |
dc.subject | tacrine | en_US |
dc.title | Polymer drug conjugates containing memantine, tacrine and cinnamic acid: promising nanotherapeutics for the treatment of Alzheimer’s disease | en_US |
dc.type | Article | en_US |