IL-1 genotype association with a diagnosis of periodontitis: in vivo study.
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Date
2023-09-07Author
Mulder van Staden, Sune
Mulder, Riaan
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Show full item recordAbstract
Aim:
This study aimed to evaluate the periodontal risk status based on the result of the Genotype Interleukin- 1®test in patients diagnosed with chronic periodontitis.
Objective:
To evaluate a correlation between Genotype Interleukin- 1® positivity and bacterial species at baseline for lowand high-risk patients.
To evaluate a correlation between Genotype Interleukin- 1® positivity and clinical parameters (PPD, REC,CAL, BOP, PI) of periodontal disease of low and high-risk patients at baseline
Methods:
The periodontal risk status of 25 patients diagnosed with chronic periodontitis was assessedperforming a buccal cheek swap with the Genotype Interleukin- 1® kit at baseline (prior to starting periodontaltreatment). A positive Genotype Interleukin- 1® (indicating high risk) was then evaluated against bacterialspecies parameters and the presence of clinical parameters indicative of periodontitis in patients indicated aslow or high risk.
Results:
7 of the 25 patients were identified as high risk for the development of periodontitis (GenotypeInterleukin- 1 positive).
There were no significant differences in the mean values comparing the baseline bacterial species parametersand clinical parameters between high and low-risk groups.
Conclusions:
The conclusion was that irrespective of patients having a high versus low risk genotype at baseline, the differences in the bacterial and clinical parameters were not statistically significant.