Browsing by Author "Egieyeh, Samuel Ayodele"
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Cheminformatic Characterization of Natural Antimicrob al Products for the Development of New Lead Compounds
Egieyeh, Samuel Ayodele; Oselusi, Samson Olaitan; Christoffels, Alan (MDPI, 2021)The growing antimicrobial resistance (AMR) of pathogenic organisms to currently pre- scribed drugs has resulted in the failure to treat various infections caused by these superbugs. Therefore, to keep pace with the ... -
Phytochemical components and GC–MS analysis of Petiveria alliaceae L. fractions and volatile oils
Egieyeh, Samuel Ayodele; Ogunlakin, Akingbolabo Daniel; Adesanya, Enitan Omobolanle (De Gruyter, 2023)Phytochemical constituents are important in the determination of plant activities. Their presence in medicinal plants gives their therapeutic values. These phytoconstituents possesses pharmacological activities that include ... -
Polymer drug conjugates containing memantine, tacrine and cinnamic acid: promising nanotherapeutics for the treatment of Alzheimer’s disease
Naki, Tobeka; Egieyeh, Samuel Ayodele; Matshe, William Morwa Reagile (Taylor and Francis Ltd., 2023)Aim: To prepare polymer-drug conjugates containing a combination of memantine, tacrine, and E)-N-(3-aminopropyl)cinnamide, promising therapeutics for the treatment of neurodegenerative disorders. Methods: The conjugates ... -
Prioritization of anti-malarial hits from nature: Chemo-informatic profiling of natural products with in vitro antiplasmodial activities and currently registered anti-malarial drugs
Egieyeh, Samuel Ayodele; Syce, James; Malan, Sarel F. (BMC, 2016)A large number of natural products have shown in vitro antiplasmodial activities. Early identification and prioritization of these natural products with potential for novel mechanism of action, desirable pharmacokinetics ...