Oral medicine case book 61: Oral malignant melanoma
Date
2014Author
Mosalleum, E.
Afrogheh, Amir
Dreyer, Wynand P.
Schneider, J.W.
Metadata
Show full item recordAbstract
A 45-year old male patient presented at the Oral and Maxillofacial
Clinic, Tygerberg, with a pathological fracture of the left
mandible following an extraction. The medical records of the
patient revealed a history of multiple myeloma that was treated
with Aredia (pamidronate disodium, an intravenous form of bisphosphonate),
cyclophosphamide (an alkylating agent) and
dexamethaxone (an anti-inflammatory and immunosuppressant
drug). An orthopantomograph revealed osteonecrosis
and pathological fracture of the left mandible, thought to be
due to the earlier biphosphonate administration. The patient
received conservative management for the osteonecrosis
and was stable at the time of the publication, (19 months after
the initial presentation with the pathological fracture).