Antimicrobial activities of a novel biflavonoid and other constituents from Rhus natalensis

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Date
2013Author
Mwangi, Henry M.
Mabusela, Wilfred T.
Abegaz, Berhanu M.
Martin, Onani O.
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Show full item recordAbstract
Phytochemical studies on Rhus natalensis root bark collected from Kenya led to the isolation and
identification of a new biflavonoid (3-(1-(2,4-dihydroxyphenyl)-3,3-bis(4-hydroxyphenyl)-1-oxopropan-2-
yl)-7-methoxy-4H-chromone-4-one (1), named rhuschromone, in addition to two other known
compounds; 2',4'-dihydroxychalcone-(4-O-5''')-4'',2''',4'''-trihydroxychalcone (2) and 3-((Z)-heptadec-13-
enyl) benzene-1,2-diol (3). The chemical structures of the isolated compounds were established using
spectroscopic techniques including high field nuclear magnetic resonance (NMR). The total extracts
and the isolated compounds were tested for their antimicrobial activities against different strains of
bacteria.