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    Trends in Genotypic HIV-1 Antiretroviral resistance between 2006 and 2012 in South African Patients receiving first- and second line antiretroviral treatment regimens

    Trends in Genotypic HIV-1 Antiretroviral resistance between 2006 and 2012 in South African Patients receiving first- and second line antiretroviral treatment regimens

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    Van Zyl_Trends in Genotypic HIV-1_2013.pdf (276.4Kb)
    Date
    2013
    Author
    Van Zyl, Gert U.
    Liu, Tommy F.
    Claassen, Mathilda
    Engelbrecht, Susan
    de Oliveira, Tulio
    Preiser, Wolfgang
    Wood, Natasha T.
    Travers, Simon A.
    Shafer, Robert W.
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    Abstract
    South Africa's national antiretroviral (ARV) treatment program expanded in 2010 to include the nucleoside reverse transcriptase (RT) inhibitors (NRTI) tenofovir (TDF) for adults and abacavir (ABC) for children. We investigated the associated changes in genotypic drug resistance patterns in patients with first-line ARV treatment failure since the introduction of these drugs, and protease inhibitor (PI) resistance patterns in patients who received ritonavir-boosted lopinavir (LPV/r)-containing therapy.
     
    South Africa's national antiretroviral (ARV) treatment program expanded in 2010 to include the nucleoside reverse transcriptase (RT) inhibitors (NRTI) tenofovir (TDF) for adults and abacavir (ABC) for children. We investigated the associated changes in genotypic drug resistance patterns in patients with first-line ARV treatment failure since the introduction of these drugs, and protease inhibitor (PI) resistance patterns in patients who received ritonavir-boosted lopinavir (LPV/r)-containing therapy.
     
    URI
    http://hdl.handle.net/10566/2544
    http://dx.doi.org/10.1371/journal.pone.0067188
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