Trends in Genotypic HIV-1 Antiretroviral resistance between 2006 and 2012 in South African Patients receiving first- and second line antiretroviral treatment regimens
Trends in Genotypic HIV-1 Antiretroviral resistance between 2006 and 2012 in South African Patients receiving first- and second line antiretroviral treatment regimens
Date
2013Metadata
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South Africa's national antiretroviral (ARV) treatment program expanded in 2010 to include the nucleoside
reverse transcriptase (RT) inhibitors (NRTI) tenofovir (TDF) for adults and abacavir (ABC) for children. We investigated the
associated changes in genotypic drug resistance patterns in patients with first-line ARV treatment failure since the
introduction of these drugs, and protease inhibitor (PI) resistance patterns in patients who received ritonavir-boosted
lopinavir (LPV/r)-containing therapy. South Africa's national antiretroviral (ARV) treatment program expanded in 2010 to include the nucleoside
reverse transcriptase (RT) inhibitors (NRTI) tenofovir (TDF) for adults and abacavir (ABC) for children. We investigated the
associated changes in genotypic drug resistance patterns in patients with first-line ARV treatment failure since the
introduction of these drugs, and protease inhibitor (PI) resistance patterns in patients who received ritonavir-boosted
lopinavir (LPV/r)-containing therapy.
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