dc.contributor.author | Williams, Monray Edward | |
dc.contributor.author | Fielding, Burtram Clinton | |
dc.date.accessioned | 2021-10-13T11:48:59Z | |
dc.date.available | 2021-10-13T11:48:59Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Williams, M. E., & Fielding, B. C. (2021). Insult to injury-potential contribution of Coronavirus disease-19 to neuroinflammation and the development of HIV-associated neurocognitive disorders. AIDS Research and Human Retroviruses, 37(8), 601–609. https://doi.org/10.1089/aid.2020.0136 | en_US |
dc.identifier.issn | 1931-8405 | |
dc.identifier.uri | 10.1089/aid.2020.0136 | |
dc.identifier.uri | http://hdl.handle.net/10566/6901 | |
dc.description.abstract | HIV-associated neurocognitive disorders (HAND)
are consequences of the effects of HIV-1 within the
central nervous system (CNS).1,2 HAND are classified according to impairment severity, namely, asymptomatic neurocognitive impairment, mild neurocognitive impairment, or
HIV-associated dementia.3,4
In the modern antiretroviral therapy (ART) era, the more
severe forms of HAND have significantly decreased, however, milder forms are persisting in 50% of people living with
HIV (PLWH).5 Currently, the underlying neuropathophysiological mechanisms of HAND remain unclear. However,
the common hypothesis for the persistence of HAND in the
modern ART era is the continued immune activation and
low-grade inflammation experienced by PLWH. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Mary Ann Liebert | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Coronaviruses | en_US |
dc.subject | HIV | en_US |
dc.subject | Neurocognitive disorders | en_US |
dc.subject | Inflammation | en_US |
dc.title | Insult to injury-potential contribution of Coronavirus disease-19 to neuroinflammation and the development of HIV-associated neurocognitive disorders | en_US |
dc.type | Article | en_US |