Browsing School of Natural Medicine by Author "Leisegang, Kristian"
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Effect of the metabolic syndrome on male reproductive function: a case-controlled pilot study
Leisegang, Kristian; Bouic, Patrick J.D.; Henkel, Ralf (Wiley, 2014)The metabolic syndrome (MetS) is a constellation of various risk factors. This study aimed to investigate the effect of MetS on testosterone and progesterone, and semen parameters, in a case-controlled pilot study. Male ... -
The efficacy of zingiber officinale on dyslipidaemia, blood pressure, and inflammation as cardiovascular risk factors: A systematic review
Daniels, Chelsea Courtney; Isaacs, Zaiyaan; Leisegang, Kristian; Finelli, Renata (Clinical Nutrition ESPEN, 2022)Background & aims: Hypertension, dyslipidaemia, and chronic inflammation contribute to the development of cardiovascular disease (CVD). Zingiber officinale has been suggested to reduce these CVD risk factors; however, the ... -
The impact of male overweight on semen quality and outcome of assisted reproduction
Leisegang, Kristian; Henkel, Ralf (Medknow Publications, 2014)The impact of obesity on male reproductive health remains a contested topic as evidence is inconclusive and inconsistent. Even more debatable is the effect of male obesity in assisted reproduction. In the manuscript, ... -
The in vitro modulation of steroidogenesis by inflammatory cytokines and insulin in TM3 Leydig cells
Leisegang, Kristian; Henkel, Ralf (BioMed Central, 2018)BACKGROUND: Cytokines and hormones, including insulin, are known to modulate the hypothalamic-pituitary-testes axis and steroidogenesis, both centrally and peripherally. In the context of chronic inflammation and hyper ... -
Male fertility and the COVID-19 pandemic: Systematic review of the literature
Leisegang, Kristian; Khalili, Mohammad Ali; Majzoub, Ahmad A. (Korean Society for Sexual Medicine and Andrology, 2020)Purpose: Since its discovery in December 2019, the novel coronavirus SARS-CoV-2 has spread globally, causing the current COVID-19 (coronavirus disease-19) pandemic. As there is an increase of infections in the male population, ... -
Nutritional value of cooked offal derived from free-range rams reared in South Africa
Hoffman, L.C.; Laubscher, L.L.; Leisegang, Kristian (Elsevier, 2013)Nutritional value of Dorper (n=10) and Merino (n=10) by-products were evaluated. Proximate composition differed between organs and breeds with Merino heart (68.9 g/100 g), spleen (77.2 g/100 g) and testicles (83.7 g/100 ... -
Obesity is associated with increased seminal insulin and leptin alongside reduced fertility parameters in a controlled male cohort
Leisegang, Kristian; Menkveld, Roelof; Bouic, Patrick J.D.; Henkel, Ralf (BioMed Central, 2014)Obesity appears to be associated with male reproductive dysfunction and infertility, although this has been inconsistent and inconclusive. Insulin and leptin are known mediators and modulators of the hypothalamus-pituitary-testes ... -
Sperm DNA fragmentation: A new guideline for clinicians
Leisegang, Kristian; Agarwal, Ashok; Majzoub, Ahmad A. (Korean Society for Sexual Medicine and Andrology, 2020)Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases of spermatogenesis, which imparts compaction ... -
Utility of Antioxidants in the Treatment of Male Infertility: Clinical Guidelines Based on a Systematic Review and Analysis of Evidence
Leisegang, Kristian; Agarwal, Ashok; Majzoub, Ahmad (The Worlds Journal of Men's health, 2021-01)It is widely accepted that oxidative stress plays an important role in the pathophysiology of male infertility and that antioxidants could have a significant role in the treatment of male infertility. The main objectives ... -
A web-based global educational model for training in semen analysis during the Covid-19 pandemic
Agarwal, Ashok; Finelli, Renata; Leisegang, Kristian (Korean Society for Sexual Medicine and Andrology, 2021)In response to the COVID-19 pandemic, the American Center for Reproductive Medicine (ACRM) transitioned its annual training in assisted reproductive technology (ART) from a hands-on, laboratory-based training course to a ...