Show simple item record

dc.contributor.authorEllis, Christa
dc.contributor.authorKruger, Herculina S
dc.contributor.authorViljoen, Michelle
dc.date.accessioned2021-11-09T11:37:20Z
dc.date.available2021-11-09T11:37:20Z
dc.date.issued2021
dc.identifier.citationEllis, C. et al. (2021). Factors associated with bone mineral density and bone resorption markers in postmenopausal hiv-infected women on antiretroviral therapy: A prospective cohort study. Nutrients, 13(6),2090. https://doi.org/10.3390/nu13062090en_US
dc.identifier.issn2072-6643
dc.identifier.urihttps://doi.org/10.3390/nu13062090
dc.identifier.urihttp://hdl.handle.net/10566/6997
dc.description.abstractThe study aimed to determine factors associated with changes in bone mineral density (BMD) and bone resorption markers over two years in black postmenopausal women living with human immunodeficiency virus (HIV) on antiretroviral therapy (ART). Women (n = 120) aged > 45 years were recruited from Potchefstroom, South Africa. Total lumbar spine and left femoral neck (LFN) BMD were measured with dual energy X-ray absorptiometry. Fasting serum C-Telopeptide of Type I collagen (CTx), vitamin D and parathyroid hormone were measured. Vitamin D insufficiency levels increased from 23% at baseline to 39% at follow up. In mixed linear models serum CTx showed no change from baseline to end (p = 0.363, effect size = 0.09). Total and LFN BMD increased significantly over two years, but effect sizes were small. No significant change in spine BMD over time was detected (p = 0.19, effect size = 0.02). Age was significantly positively associated with CTx over time, and negatively with total and LFN BMD. Physical activity (PA) was positively associated with LFN BMD (p = 0.008). Despite a decrease in serum vitamin D, BMD and CTx showed small or no changes over 2 years. Future studies should investigate PA interventions to maintain BMD in women living with HIV.en_US
dc.language.isoenen_US
dc.publisherMPDIen_US
dc.subjectBone mineral densityen_US
dc.subjectBlacken_US
dc.subjectPostmenopausalen_US
dc.subjectHIV-infected womenen_US
dc.subjectCalciumen_US
dc.titleFactors associated with bone mineral density and bone resorption markers in postmenopausal hiv-infected women on antiretroviral therapy: A prospective cohort studyen_US
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record