Research Articles (Medical Bioscience): Recent submissions
Now showing items 161-180 of 258
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B-cell and T-cell activation in South African HIV-1-positive non-Hodgkin’s lymphoma patients
(AOSIS, 2018)BACKGROUND: Altered immune mechanisms play a critical role in the pathogenesis of non- Hodgkin’s lymphoma (NHL). HIV-1 (HIV) infection is associated with a state of excessive T-cell activation, which can lead to increased ... -
Microtubular dysfunction and male infertility
(Korean Society for Sexual Medicine and Andrology, 2018)Microtubules are the prime component of the cytoskeleton along with microfilaments. Being vital for organelle transport and cellular divisions during spermatogenesis and sperm motility process, microtubules ascertain ... -
The excessive use of antioxidant therapy: A possible cause of male infertility?
(Wiley, 2018)Reactive oxygen species and oxidative stress are closely associated with various pathologies such as neurodegenerative diseases, ageing and male infertility. Hence, antioxidants such as vitamin C, vitamin E, N‐acetyl ... -
Smoking‐induced genetic and epigenetic alterations in infertile men
(Wiley, 2018)Male fertility rates have shown a progressive decrease in both developing and industrialised countries in the past 50 years. Clinical and epidemiological studies have demonstrated controversial results about the harmful ... -
Reactive oxygen species and male reproductive hormones
(BMC, 2018)Reports of the increasing incidence of male infertility paired with decreasing semen quality have triggered studies on the effects of lifestyle and environmental factors on the male reproductive potential. There are ... -
Quantitative assessment of heavy metal effects on sperm function using computer‐aided sperm analysis and cytotoxicity assays
(Wiley, 2018)One known environmental risk factor impacting on human reproduction is heavy metal pollution. Although some metals (e.g., Cu, Se and Zn) have protective effects on the male reproductive system in low doses, heavy metals ... -
Reactive oxygen species and male reproductive hormones
(BMC, 2018)Reports of the increasing incidence of male infertility paired with decreasing semen quality have triggered studies on the effects of lifestyle and environmental factors on the male reproductive potential. There are ... -
Rutin as a potent antioxidant: implications for neurodegenerative disorders
(Hindawi Publishing Corporation, 2018)A wide range of neurodegenerative diseases (NDs), including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and prion diseases, share common mechanisms such as neuronal loss, apoptosis, mitochondrial ... -
CASA in invertebrates
(CSIRO Publishing, 2018)Sperm movement has been described in several phyla of invertebrates. Yet, sperm motility has only been quantified using computer-aided sperm analysis (CASA-Mot) in externally fertilising species (broadcast spawners) of ... -
The effects of carbon dots on immune system biomarkers, using the Murine Macrophage cell line RAW 264.7 and human whole blood cell cultures
(MDPI, 2018)Abstract: Carbon dots (CDs) are engineered nanoparticles that are used in a number of bioapplications such as bioimaging, drug delivery and theranostics. The effects of CDs on the immune system have not been evaluated. ... -
Vaginal microbiomes associated with aerobic vaginitis and bacterial vaginosis
(Frontiers Media, 2018)A healthy vaginal microbiota is considered to be significant for maintaining vaginal health and preventing infections. However, certain vaginal bacterial commensal species serve an important first line of defense of the ... -
Effects of graphene oxide nanoparticles on the immune system biomarkers produced by RAW264.7 and human whole blood cell cultures
(MDPI, 2018)Graphene oxide nanoparticles (GONPs) have attracted a lot of attention due to their many applications. These applications include batteries, super capacitors, drug delivery and biosensing. However, few studies have ... -
MERS-CoV: Understanding the latest human coronavirus threat
(MDPI, 2018)Human coronaviruses cause both upper and lower respiratory tract infections in humans. In 2012, a sixth human coronavirus (hCoV) was isolated from a patient presenting with severe respiratory illness. The 60-year-old man ... -
Microstructurally-based constitutive modelling of the skin – Linking intrinsic ageing to microstructural parameters
(Elsevier, 2018)A multiphasic constitutive model of the skin that implicitly accounts for the process of intrinsic (i.e. chronological) ageing via variation of the constitutive parameters is proposed. The structurally-motivated constitutive ... -
The relationship between seminal leukocytes, oxidative status in the ejaculate, and apoptotic markers in human spermatozoa
(Taylor & Francis, 2013)The aim of this study was to investigate the relationship between seminal leukocytes, reactive oxygen species (ROS) production in the ejaculate, and markers of apoptosis in human spermatozoa. Semen samples were collected ... -
Autosomal recessive congenital cataract in captive-bred vervet monkeys (Chlorocebus aethiops)
(Wiley, 2018)BACKGROUND: The aim of the study was to evaluate the genetic predisposition of congenital cataract in a colony of captive-bred vervet monkeys. METHODS: Four congenital cataract genes: glucosaminyl (N-acetyl) transferase ... -
Evaluation of reference values of standard semen parameters in fertile Egyptian men
(Wiley, 2018)The reference values of human semen, published in the WHO’s latest edition in 2010, were lower than those previously reported. The objective of this study was to evaluate reference values of standard semen parameters in ... -
Relative contribution of various chronic diseases and multi-morbidity to potential disability among Dutch elderly
(2018, 2018)BACKGROUND: The amount of time spent living with disease greatly influences elderly people’s wellbeing, disability and healthcare costs, but differs by disease, age and sex. METHODS: We assessed how various single and ... -
Calibration of redox potential in sperm wash media and evaluation of oxidation–reduction potential values in various assisted reproductive technology culture media using MiOXSYS system
(Wiley, 2018)Oxidation–reduction potential describes the balance between the oxidants and antioxidants in fluids including semen. Various artificial culture media are used in andrology and IVF laboratories for sperm preparation and to ... -
Human sperm handling in intracytoplasmic sperm injection processes: In vitro studies on mouse oocyte activation, embryo development competence and sperm oxidation–reduction potential
(Wiley, 2018)Polyvinylpyrrolidone (PVP) and hyaluronic acid (HA) are routinely used in handling spermatozoa for intracytoplasmic sperm injection (ICSI). As there are still concerns about possible adverse effects on the embryo, this ...