Browsing South African National Bioinformatics Institute (SANBI) by Author "Dorfman, Jeffrey R."
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Structural rearrangements maintain the Glycan Shield of an HIV-1 envelope trimer after the loss of a glycan
Ferreira, Roux-Cil; Grant, Oliver C.; Moyo, Thandeka; Dorfman, Jeffrey R.; Woods, Robert J.; Travers, Simon A.; Wood, Natasha T. (Nature Research, 2018)The HIV-1 envelope (Env) glycoprotein is the primary target of the humoral immune response and a critical vaccine candidate. However, Env is densely glycosylated and thereby substantially protected from neutralisation. ...