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Prioritization of candidate genes for a South African family with Parkinson’s disease using in-silico tools
(Public Library of Science, 2021)
Parkinson's disease (PD) is a neurodegenerative disorder exhibiting Mendelian inheritance in some families. Next-generation sequencing approaches, including whole exome sequencing (WES), have revolutionized the field of ...
Interaction analysis of statistically enriched mutations identified in Cameroon recombinant subtype CRF02_AG that can influence the development of Dolutegravir drug resistance mutations
(BMC, 2021)
The Integrase (IN) strand transfer inhibitor (INSTI), Dolutegravir (DTG), has been given the green light
to form part of first-line combination antiretroviral therapy (cART) by the World Health Organization (WHO). ...
Corrigendum: Synthesis and cytotoxic activity of novel indole derivatives and their in silico screening on spike glycoprotein of sars-cov-2
(Frontiers Media, 2021)
The authors Kaliappillai Vijayakumar, Magda H. Abdellattif, Mohd Shahbaaz were not included in the published article and the authors Daoud Ali, Saud Alarifi, and Amal Alotaibi were mistakenly included in the author list. ...
Synthesis of oxygen deficient tio2 for improved photocatalytic efficiency in solar radiation
(MDPI, 2021)
The photocatalytic activities of TiO2 have been limited mainly to absorbing in the ultraviolet
spectrum which accounts for only 5% of solar radiation. High energy band gap and electron
recombination in TiO2 nanoparticles ...
Antennal enriched odorant binding proteins are required for odor communication in glossina f. Fuscipes
(MPDI, 2021)
Olfaction is orchestrated at different stages and involves various proteins at each step.
For example, odorant-binding proteins (OBPs) are soluble proteins found in sensillum lymph that
might encounter odorants before ...
Transcriptomic profile of mycobacterium smegmatis in response to an imidazo[1,2-b][1,2,4,5]tetrazine reveals its possible impact on iron metabolism
(Frontiers Media, 2021)
Tuberculosis (TB), caused by the Mycobacterium tuberculosis complex bacteria, is
one of the most pressing health problems. The development of new drugs and
new therapeutic regimens effective against the pathogen is one ...
Evaluation of protein purification techniques and effects of storage duration on lc-ms/ms analysis of archived ffpe human crc tissues
(Frontiers Media, 2021)
To elucidate cancer pathogenesis and its mechanisms at the molecular level, the collecting
and characterization of large individual patient tissue cohorts are required. Since most
pathology institutes routinely preserve ...
Current perspectives in the discovery of newer medications against the outbreak of Covid-19
(Frontiers Media, 2021)
A rapid and increasing spread of COVID-19 pandemic disease has been perceived
worldwide in 2020. The current COVID-19 disease outbreak is due to the spread of
SARS-CoV-2. SARS-CoV-2 is a new strain of coronavirus that ...
Emerging evidence implicating a role for neurexins in neurodegenerative and neuropsychiatric disorders
(The Royal Society, 2021)
Synaptopathies are brain disorders characterized by dysfunctional synapses,
which are specialized junctions between neurons that are essential for the transmission of information. Synaptic dysfunction can occur due to ...
Ten simple rules for developing bioinformatics capacity at an academic institution
(Public Library of Science, 2021)
Bioinformatics is an applied interdisciplinary field whose primary purpose is to develop and
deploy computational techniques to store, organize, and aid in the analysis and interpretation
of large-scale data obtained ...