The stability and anti-angiogenic properties of titanium dioxide nanoparticles (tio2nps) using caco-2 cells
Date
2022Author
David, Oladipupo Moyinoluwa
Lategan, Kim Leigh
de Cortalezzi, Maria Fidalgo
Metadata
Show full item recordAbstract
Titanium dioxide nanoparticles (TiO2NPs) are found in a wide range of products such
as sunscreen, paints, toothpaste and cosmetics due to their white pigment and high refractive
index. These wide-ranging applications could result in direct or indirect exposure of these NPs
to humans and the environment. Accordingly, conflicting levels of toxicity has been associated
with these NPs. Therefore, the risk associated with these reports and for TiO2NPs produced using
varying methodologies should be measured. This study aimed to investigate the effects of various
media on TiO2NP properties (hydrodynamic size and zeta potential) and the effects of TiO2NP
exposure on human colorectal adenocarcinoma (Caco-2) epithelial cell viability, inflammatory and
cell stress biomarkers and angiogenesis proteome profiles.