IL-1 genotype association with a diagnosis of periodontitis: in vivo study.

Abstract

Aim: This study aimed to evaluate the periodontal risk status based on the result of the Genotype Interleukin- 1®test in patients diagnosed with chronic periodontitis. Objective: To evaluate a correlation between Genotype Interleukin- 1® positivity and bacterial species at baseline for lowand high-risk patients. To evaluate a correlation between Genotype Interleukin- 1® positivity and clinical parameters (PPD, REC,CAL, BOP, PI) of periodontal disease of low and high-risk patients at baseline Methods: The periodontal risk status of 25 patients diagnosed with chronic periodontitis was assessedperforming a buccal cheek swap with the Genotype Interleukin- 1® kit at baseline (prior to starting periodontaltreatment). A positive Genotype Interleukin- 1® (indicating high risk) was then evaluated against bacterialspecies parameters and the presence of clinical parameters indicative of periodontitis in patients indicated aslow or high risk. Results: 7 of the 25 patients were identified as high risk for the development of periodontitis (GenotypeInterleukin- 1 positive). There were no significant differences in the mean values comparing the baseline bacterial species parametersand clinical parameters between high and low-risk groups. Conclusions: The conclusion was that irrespective of patients having a high versus low risk genotype at baseline, the differences in the bacterial and clinical parameters were not statistically significant.