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Synthesis and biological evaluations of NO-donating oxa- and aza-pentacycloundecane derivatives as potential neuroprotective candidates
(MDPI, 2018)
In order to utilize the neuroprotective properties of polycyclic cage compounds, and explore
the NO-donating ability of nitrophenyl groups, an array of compounds was synthesized where the
different nitrophenyl groups ...
Neuroprotective activities of Boophone haemanthoides (amaryllidaceae) extract and its chemical constituents
(Multidisciplinary Digital Publishing Institute (MDPI), 2020)
Parkinson’s disease (PD) is a neurodegenerative condition that progresses as age increases, and some of its major symptoms include tremor and postural and movement-related difficulties. To date, the treatment of PD remains ...
4-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione derivatives as nmda receptor- And VGCC blockers with neuroprotective potential
(MPDI, 2020)
The impact of excitotoxicity mediated by N-methyl-D-aspartate (NMDA) receptor overactivation and voltage gated calcium channel (VGCC) depolarization is prominent among the postulated processes involved in the development ...
4-Oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione Derivatives as NMDA Receptor- and VGCC Blockers with Neuroprotective Potential
(MDPI, 2020)
The impact of excitotoxicity mediated by N-methyl-D-aspartate (NMDA) receptor
overactivation and voltage gated calcium channel (VGCC) depolarization is prominent among
the postulated processes involved in the development ...
Design, synthesis, and evaluation of 3,7-substituted coumarin derivatives as multifunctional Alzheimer’s disease agents
(Taylor & Francis Open Access, 2021)
Multitarget directed ligands (MTDLs) are emerging as promising treatment options for Alzheimer’s disease
(AD). Coumarin derivatives serve as a good starting point for designing MTDLs due to their inherent inhibition of ...