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Antimicrobial resistant Gram-positive cocci in pregnant mothers with aerobic vaginitis
(Infection Control Africa Network (ICAN), 2016)
The vaginal microbiota of a healthy asymptomatic woman consists of an extensive diversity of anaerobic and aerobic bacterial genera and species dominated by the microaerophilic genus Lactobacillus , known to inhibit the ...
Small molecule efflux pump inhibitors in Mycobacterium tuberculosis: a rational drug design perspective
(Bentham Science Publishers, 2018)
Drug resistance in Mycobacterium tuberculosis (M. tuberculosis) complicates management of tuberculosis. Efflux pumps contribute to low level resistance and acquisition of additional high level resistance mutations through ...
Candida antifungal drug resistance in sub-Saharan African populations: A systematic review
(Science Navigation Group, 2017)
BACKGROUND: Candida infections are responsible for increased morbidity and mortality rates in at-risk patients, especially in developing countries where there is limited access to antifungal drugs and a high burden of HIV ...
Carbapenem resistance expressed by Gram-negative bacilli isolated from a cohort of Libyan patients
(BioMed Central, 2016)
Background and objectives: Carbapenem-resistant Enterobacteriaceae (CRE) and other Gram-negative bacteria are among the most common pathogens responsible for both community and hospital acquired infection. The global spread ...
Rare fungal species isolated from Libyan diabetic patients
(Infection Control Africa Network (ICAN), 2016)
BACKGROUND AND OBJECTIVES: The emerging resistance of Candida species to antifungals routinely used to treat candidiasis in HIV patients and in patients with diabetes mellitus (DM) has resulted in the frequent isolation ...
Colistin, Carbapenem and Cephalosporin-resistant Klebsiella pneumoniae reported from Misrata, Libya
(Medpharm Publications, 2017)
Background: National surveillance of antimicrobial resistance has become a mandatory approach to control the spread of antimicrobial resistance and for the establishment of antibiotic treatment guidelines. In this study, ...
Molecular dynamic simulations to investigate the structural impact of known drug resistance mutations on HIV-1C integrase-dolutegravir binding
(Public Library of Science, 2020)
Resistance associated mutations (RAMs) threaten the long-term success of combination antiretroviral therapy (cART) outcomes for HIV-1 treatment. HIV-1 Integrase (IN) strand transfer inhibitors (INSTIs) have proven to be a ...
Characterizing the emergence and persistence of drug resistant mutations in HIV-1 subtype C infections using 454 ultra deep pyrosequencing
(BioMed Central -The Open Access Publisher, 2013)
BACKGROUND: The role of HIV-1 RNA in the emergence of resistance to antiretroviral therapies (ARTs) is well
documented while less is known about the role of historical viruses stored in the proviral DNA. The primary ...
Proteomics of drug-resistant HIV-associated candidiasis
(University of the Western Cape, 2015)
Candidiasis and HIV co-infection may cause increased patient morbidity and mortality due to oropharyngeal or systemic dissemination. Limited information exists on the prevalence, antifungal susceptibility profiles and drug ...
Transcriptomic profile of mycobacterium smegmatis in response to an imidazo[1,2-b][1,2,4,5]tetrazine reveals its possible impact on iron metabolism
(Frontiers Media, 2021)
Tuberculosis (TB), caused by the Mycobacterium tuberculosis complex bacteria, is
one of the most pressing health problems. The development of new drugs and
new therapeutic regimens effective against the pathogen is one ...