Browsing Biotechnology by Title
Now showing items 90-109 of 233
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Gene expression alterations and molecular analysis of CHEK1 in solid tumors
(MDPI, 2020)Alterations in the Checkpoint kinase (CHEK1) gene, its regulation, and the possible clinical outcomes in human solid tumors have not been previously examined. Therefore, the present study was carried out to evaluate the ... -
Gene expression modulation of apoptotic and oestrogen receptor alpha genes by active fractions of selected Nigerian plants on cervical cancer cell line (hela)
(University of Benin, 2021)The roles of natural product in drug discovery and development cannot be over emphasised. It plays a vital role in human therapy and gives a better understanding on the cellular pathways.This study investigated the ... -
Genetic association of solute carrier transporter gene variants with metformin response
(Balkan Journal of Medical Genetics, 2021)Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by elevated blood glucose levels and is influenced by both genetic and environmental factors. It is treated with various classes of oral antidiabetic ... -
Genetic characterisation of Campylobacter concisus: Strategies for improved genomospecies discrimination
(Elsevier, 2021)Although at least two genetically distinct groups, or genomospecies, have been well documented for Campylobacter concisus, no phenotype has yet been identified for their differentiation and thus formal description as ... -
Genetic characterization of the central variable region in African swine fever virus isolates in the Russian federation from 2013 to 2017
(MDPI, 2022)African swine fever virus (ASFV), classified as genotype II, was introduced into Georgia in 2007, and from there, it spread quickly and extensively across the Caucasus to Russia, Europe and Asia. The molecular epidemiology ... -
Genetic diversity, population structure and marker- trait association for 100-seed weight in international safflower panel using silicodart marker information
(MDPI, 2020)Safflower is an important oilseed crop mainly grown in the arid and semi-arid regions of the world. The aim of this study was to explore phenotypic and genetic diversity, population structure, and marker-trait association ... -
Genetic heritage of the Baphuthi highlights an over-ethnicized notion of “Bushman” in the Maloti-Drakensberg, southern Africa
(Cell Press, 2023)Using contemporary people as proxies for ancient communities is a contentious but necessary practice in anthropology. In southern Africa, the distinction between the Cape KhoeSan and eastern KhoeSan remains unclear, as ... -
Genetic landscape of the mitochondrial DNA control region in South African populations
(ScienceDirect, 2019)A high-quality dataset of the mitochondrial DNA control region sequences was generated with Sanger and next-generation sequencing. The study was aimed at characterizing the maternal genetic ancestry and analyzing the ... -
Genetic polymorphisms and haplotypes of the organic cation transporter 1 gene (SLC22A1) in the Xhosa population of South Africa
(Brazilian Society of Genetics, 2014)Human organic cation transporter 1 is primarily expressed in hepatocytes and mediates the electrogenic transport of various endogenous and exogenous compounds, including clinically important drugs. Genetic polymorphisms ... -
Genetic preservation of SLC22A3 in the Admixed and Xhosa populations living in the Western Cape
(Springer Science and Business Media B.V., 2023)Background Amphiphilic solute facilitator organic cation transporters mediate the movement of various endogenous and exogenous organic cations, including crucial drugs like metformin, oxaliplatin, and lamivudine. These ... -
Genetic variation and population structure of Botswana populations as identified with AmpFLSTR Identifiler short tandem repeat (STR) loci
(Nature Publishing Group, 2017-07-28)Population structure was investigated in 990 Botswana individuals according to ethno-linguistics, Bantu and Khoisan, and geography (the nine administrative districts) using the Identifiler autosomal microsatellite markers. ... -
Genetic variation in responses to salt stress in Tunisian populations of Medicago ciliaris
(MDPI, 2022)Soil salinity is one of the most serious environmental factors affecting crop productivity around the world. We used a morpho-physiological approach to investigate the salt responses of four Tunisian natural populations ... -
Genome sequences of three vaccine strains and two wild-type canine distemper virus strains from a recent disease outbreak in South Africa
(American Society for Microbiology, 2017)Canine distemper virus causes global multihost infectious disease. This report details complete genome sequences of three vaccine and two new wild-type strains. The wild-type strains belong to the South African lineage, ... -
Genomic association of single nucleotide polymorphisms with blood pressure response to hydrochlorothiazide among south african adults with hypertension
(MDPI, 2020): This study described single nucleotide polymorphisms (SNPs) in hydrochlorothiazideassociated genes and further assessed their correlation with blood pressure control among South African adults living with hypertension. ... -
Genomic characterization of a prophage, Smhb1, that Infects Salinivibrio kushneri BNH isolated from a Namib Desert saline spring
(MDPI, 2021)Recent years have seen the classification and reclassification of many viruses related to the model enterobacterial phage P2. Here, we report the identification of a prophage (Smhb1) that infects Salinivibrio kushneri BNH ... -
GlobalFiler® express DNA amplification kit in South Africa: Extracting the past from the present
(Elsevier, 2016)In this study, the GlobalFiler1 Express amplification kit was evaluated for forensic use in 541 South African individuals belonging to the Afrikaaner, amaXhosa,1 amaZulu,1 Asian Indian and Coloured population groups. Allelic ... -
Glucose-uptake activity and cytotoxicity of diterpenes and triterpenes isolated from lamiaceae plant species
(2020)The prevalence of diabetes mellitus (DM), considered one of the most common metabolic disorders, has dramatically increased and resulted in higher rates of morbidity and mortality around the world in the past decade. It ... -
Gold nanoparticles synthesized using extracts of cyclopia intermedia, commonly known as honeybush, amplify the cytotoxic effects of doxorubicin
(MPDI, 2021)Cyclopia intermedia (C. intermedia) is an indigenous South African shrub used to prepare the popular medicinal honeybush (HB) tea. This plant contains high levels of mangiferin (MGF), a xanthonoid that was reported to have ... -
Green synthesis of iron oxide (hematite) nanoparticles and their influence on sorghum bicolor growth under drought stress
(MDPI, 2023)Drought is a major abiotic stress that confronts plant growth and productivity, thus compromising food security. Plants use physiological and biochemical mechanisms to cope with drought stress, but at the expense of ... -
Green synthesis of metallic nanoparticles using some selected medicinal plants from Southern Africa and their biological applications
(MPDI, 2021)The application of metallic nanoparticles (MNPs), especially that of silver, gold, cobalt, and zinc as antimicrobial, anticancer, drug delivery, contrast, and bioimaging agents has transformed the field of medicine. Their ...