Browsing Biotechnology by Author "Sibuyi, Nicole Remaliah Samantha"
Now showing items 1-17 of 17
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Anticancer and drug-sensitizing activities of gold nanoparticles synthesized from cyclopia genistoides (honeybush) extracts
Sharma, Jyoti Rajan; Sibuyi, Nicole Remaliah Samantha; Fadaka, Adewale Oluwaseun (MDPI, 2023)Synthesis of gold nanoparticles (AuNPs) using phytochemicals has become tremendously prominent in biomedical applications because of its enhanced bioactivity and biocompatibility. In this study, water extracts from the ... -
Aptamer-Based Diagnostic Systems for the Rapid Screening of TB at the Point-of-Care
Darius, Riziki; Sibuyi, Nicole Remaliah Samantha; Oluwaseun, Fadaka Adewale (MDPI, 2021)The transmission of Tuberculosis (TB) is very rapid and the burden it places on health care systems is felt globally. The effective management and prevention of this disease requires that it is detected early. Current TB ... -
Computational insight of dexamethasone against potential targets of SARS-CoV-2
Fadaka, Adewale Oluwaseun; Sibuyi, Nicole Remaliah Samantha; Madiehe, Abram Madimabe (Taylor and Francis Group, 2022)The health sector has been on the race to find a potent therapy for coronavirus disease (COVID)-19, a diseases caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2. Repurposed anti-viral drugs have played ... -
Development of Effective Therapeutic Molecule from Natural Sources against Coronavirus Protease
Fadaka, Adewale Oluwaseun; Sibuyi, Nicole Remaliah Samantha; Martin, Darius Riziki; Klein, Ashwil (MDPI, 2021)Abstract: The SARS-CoV-2 main protease (Mpro) is one of the molecular targets for drug design. Effective vaccines have been identified as a long-term solution but the rate at which they are being administered is slow in ... -
Differentially expressed serum proteins from obese Wistar rats as a risk factor for obesity-induced diseases
Gabuza, Kwazi B.; Sibuyi, Nicole Remaliah Samantha; Mobo, Mmabatho Peggy (Springer Nature, 2020)Obesity is a chronic disease that negatively affects life expectancy through its association with life-threatening diseases such as cancer and cardiovascular diseases. Expression proteomics combined with in silico interaction ... -
Enhanced anti-bacterial activity of biogenic silver nanoparticles synthesized from terminalia mantaly extracts
Majoumouo, Michele Stella; Sibuyi, Nicole Remaliah Samantha; Tincho, Marius Belmondo (Dove Press, 2019)The global increase in outbreaks and mortality rates associated with multidrug- resistant (MDR) bacteria is a major health concern and calls for alternative treatments. Natural-derived products have shown potential in ... -
Gene expression alterations and molecular analysis of CHEK1 in solid tumors
Fadaka, Adewale Oluwaseun; Bakare, Olalekan Olanrewaju; Sibuyi, Nicole Remaliah Samantha (MDPI, 2020)Alterations in the Checkpoint kinase (CHEK1) gene, its regulation, and the possible clinical outcomes in human solid tumors have not been previously examined. Therefore, the present study was carried out to evaluate the ... -
Gold nanoparticles synthesized using extracts of cyclopia intermedia, commonly known as honeybush, amplify the cytotoxic effects of doxorubicin
Sibuyi, Nicole Remaliah Samantha; Aboyewa, Jumoke A.; Meyer, Mervin (MPDI, 2021)Cyclopia intermedia (C. intermedia) is an indigenous South African shrub used to prepare the popular medicinal honeybush (HB) tea. This plant contains high levels of mangiferin (MGF), a xanthonoid that was reported to have ... -
Green synthesis of metallic nanoparticles using some selected medicinal plants from southern africa and their biological applications
Sibuyi, Nicole Remaliah Samantha; Meyer, Mervin; Aboyewa, J.A.; Oguntibeju, O.O. (MDPI, 2021)The application of metallic nanoparticles (MNPs), especially that of silver, gold, cobalt, and zinc as antimicrobial, anticancer, drug delivery, contrast, and bioimaging agents has transformed the field of medicine. Their ... -
Immunoinformatics design of a novel epitope-based vaccine candidate against dengue virus
Oluwaseun, Fadaka Adewale; Sibuyi, Nicole Remaliah Samantha; Darius, Riziki (Springer, 2021-10)Dengue poses a global health threat, which will persist without therapeutic intervention. Immunity induced by exposure to one serotype does not confer long-term protection against secondary infection with other serotypes ... -
Inhibitory potential of repurposed drugs against the SARS-CoV-2 main protease: A computational-aided approach
Fadaka, Adewale Oluwaseun; Aruleba, Raphael Taiwo; Sibuyi, Nicole Remaliah Samantha (Taylor and Francis, 2020)The exponential increase in cases and mortality of coronavirus disease (COVID-19) has called for a need to develop drugs to treat this infection. Using in silico and molecular docking approaches, this study investigated ... -
MicroRNA-based regulation of Aurora A kinase in breast cancer
Sibuyi, Nicole Remaliah Samantha; Fadaka, Adewale Oluwaseun; Madiehe, Abram Madimabe (Impact Journals, 2020)The involvement of non-coding RNAs (ncRNAs) in cellular physiology and disease pathogenesis is becoming increasingly relevant in recent years specifically in cancer research. Breast cancer (BC) has become a health concern ... -
Nanotechnology-based delivery systems for antimicrobial peptides
Adewale, Oluwaseun Fadaka; Sibuyi, Nicole Remaliah Samantha; Madiehe, Abram Madimabe; Meyer, Mervin (MDPI, 2021)Antimicrobial resistance (AMR) is a significant threat to global health. The conventional antibiotic pool has been depleted, forcing the investigation of novel and alternative antimicrobial strategies. Antimicrobial peptides ... -
Nanotechnology-based strategies for treatment of obesity, cancer and anti-microbial resistance: Highlights of the Department of Science and Innovation/mintek Nanotechnology Innovation centre biolabels research node at the University of the Western Cape
Sibuyi, Nicole Remaliah Samantha; Moabelo, Koena Leah; Meyer, Samantha (MDPI, 2022)Nanotechnology has recently received much interest in various fields, including medicine. South Africa (SA) was the first country in Africa to adopt the technology with the aim of enhancing the national bio-economy and ... -
Prospects of using gum Arabic silver nanoparticles in toothpaste to prevent dental caries
Ahmed, Omnia Abdelmoneim Khidir; Sibuyi, Nicole Remaliah Samantha; Fadaka, Adewale Oluwaseun (MDPI, 2023)There is growing interest in the use of green synthesized silver nanoparticles (AgNPs) to control and prevent dental diseases. The incorporation of green synthesized AgNPs into dentifrices to reduce pathogenic oral ... -
Synthesis of biogenic gold nanoparticles from terminalia mantaly extracts and the evaluation of their in vitro cytotoxic effects in cancer cells
Sharma, Jyoti R.; Sibuyi, Nicole Remaliah Samantha; Majoumouo, Michele Stella (MDPI, 202-09-12)Scientists have demonstrated the potential of plant materials as 'green' reducing and stabilizing agents for the synthesis of gold nanoparticles (AuNPs) and opened new ecofriendly horizons to develop effective and less ... -
Understanding the epidemiology, pathophysiology, diagnosis and management of SARS-CoV-2
Sibuyi, Nicole Remaliah Samantha; Fadaka, Adewale Oluwaseun; Adewale, Olusola Bolaji (SAGE, 2020)The emergence of coronavirus disease 2019 (COVID-19) in December 2019 has resulted in over 20 million cases and 741,808 deaths globally, affecting more than 200 countries. COVID-19 was declared a pandemic on 11 March 2020 ...