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Amino acids 1055 to 1192 in the S2 Region of severe acute respiratory syndrome Coronavirus S Protein induce neutralizing antibodies: Implications for the development of vaccines and antiviral agents
(American Society for Microbiology, 2005)
The spike (S) protein of the severe acute respiratory syndrome coronavirus (SARS-CoV) interacts with
cellular receptors to mediate membrane fusion, allowing viral entry into host cells; hence it is recognized as the
primary ...
Genetic lesions within the 3a gene of SARS-CoV
(BioMed Central, 2005)
A series of frameshift mutations within the 3a gene has been observed in culture-derived severe
acute respiratory syndrome coronavirus (SARS-CoV). We report here that viral RNA from clinical
samples obtained from SARS-CoV ...
The Severe Acute Respiratory Syndrome Coronavirus 3a Protein Up-Regulates Expression of Fibrinogen in Lung Epithelial Cells
(American Society for Microbiology, 2005)
Here we analyzed the gene expression profile of cells that stably express the severe acute respiratory
syndrome coronavirus (SARS-CoV) 3a protein to determine its effects on host functions. A lung epithelial
cell-line, ...
A novel cell-based binding assay system reconstituting interaction between SARS-CoV S protein and its cellular receptor
(Elsevier, 2005)
Severe acute respiratory syndrome (SARS), a life-threatening disease, is caused by the newly identified virus SARS coronavirus (SARSCoV).
In order to study the spike (S) protein of this highly contagious virus, we established ...