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Now showing items 51-60 of 62
Investigation of distinct gene expression profile patterns that can improve the classification of intermediate-risk prognosis in AML patients
(Frontiers In Genetics, 2023)
Acute myeloid leukemia (AML) is a heterogeneous type of blood cancer that generally affects the elderly. AML patients are categorized with favorable-, intermediate-, and adverse risks based on an individual’s genomic ...
Using multiplex amplicon pcr technology to efficiently and timely generate rift valley fever virus sequence data for genomic surveillance
(MDPI, 2023)
Rift Valley fever (RVF) is a febrile vector-borne disease endemic in Africa and continues
to spread in new territories. It is a climate-sensitive disease mostly triggered by abnormal rainfall
patterns. The disease is ...
Role of Indigenous and local knowledge in seasonal forecasts and climate adaptation: A case study of smallholder farmers in Chiredzi, Zimbabwe
(Elsevier, 2023)
Accessible, reliable and diverse sources of climate information are needed to inform climate change adaptation at
all levels of society, particularly for vulnerable sectors such as smallholder farming. Globally, many ...
Changes in subcutaneous adipose tissue microRNA expression in response to exercise training in African women with obesity
(Nature Research, 2022)
The mechanisms that underlie exercise-induced adaptations in adipose tissue have not been
elucidated, yet, accumulating studies suggest an important role for microRNAs (miRNAs). This study
aimed to investigate miRNA ...
Transforming RNA-Seq gene expression to track cancer progression in the multi-stage early to advanced-stage cancer development
(Public Library of Science, 2023)
Cancer progression can be tracked by gene expression changes that occur throughout early-stage to advanced-stage cancer development. The accumulated genetic changes can be detected when gene expression levels in advanced-stage ...
Variant-specific introduction and dispersal dynamics of SARS-CoV-2 in New York City – from Alpha to Omicron
(Public Library of Science, 2023)
Since the latter part of 2020, SARS-CoV-2 evolution has been characterised by the emergence of viral variants associated with distinct biological characteristics. While the main
research focus has centred on the ability ...
Exploring new genetic variants within col5a1 intron 4‐exon 5 region and tgf‐β family with risk of anterior cruciate ligament ruptures
(Wiley, 2020)
Variants within genes encoding structural and regulatory elements of ligaments have
been associated with musculoskeletal soft tissue injury risk. The role of intron 4‐exon
5 variants within the α1 chain of type V collagen ...
Predicting amplification of mycn using cpg methylation biomarkers in neuroblastoma
(Future Science Group, 2021)
Neuroblastoma is the most common extracranial solid tumor in childhood. Amplification of MYCN in neuroblastoma is a predictor of poor prognosis. Materials and methods: DNA methylation data from the TARGET data matrix were ...
Application of an in silico approach identifies a genetic locus within ITGB2, and its interactions with HSPG2 and FGF9, to be associated with anterior cruciate ligament rupture risk
(Taylor and Francis Group, 2023)
We developed a Biomedical Knowledge Graph model that is phenotype and biological functionaware
through integrating knowledge from multiple domains in a Neo4j, graph database. All
known human genes were assessed through ...
Record linkage for routinely collected health data in an African health information exchange
(Swansea University, 2023)
The Patient Master Index (PMI) plays an important role in management of patient information and
epidemiological research, and the availability of unique patient identifiers improves the accuracy when
linking patient ...