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Now showing items 31-40 of 62
Emerging evidence implicating a role for neurexins in neurodegenerative and neuropsychiatric disorders
(The Royal Society, 2021)
Synaptopathies are brain disorders characterized by dysfunctional synapses,
which are specialized junctions between neurons that are essential for the transmission of information. Synaptic dysfunction can occur due to ...
Ten simple rules for developing bioinformatics capacity at an academic institution
(Public Library of Science, 2021)
Bioinformatics is an applied interdisciplinary field whose primary purpose is to develop and
deploy computational techniques to store, organize, and aid in the analysis and interpretation
of large-scale data obtained ...
Dispersal dynamics of SARS-CoV-2 lineages during the first epidemic wave in New York City
(Public Library of Science, 2021)
During the first phase of the COVID-19 epidemic, New York City rapidly became the epicenter of the pandemic in the United States. While molecular phylogenetic analyses have previously highlighted multiple introductions and ...
A novel nano therapeutic using convalescent plasma derived exosomal (CPExo) for Covid-19: A combined hyperactive immune modulation and diagnostics
(Elsevier, 2021)
Extracellular vesicles like exosomes are important therapeutic tactics for treating COVID -19. By utilizing
convalescent plasma derived exosomes (CPExo) from COVID-19 recovered persistence could accelerate the
treatment ...
Current Status of Next-Generation Sequencing Approaches for Candidate Gene Discovery in Familial Parkinson´s Disease
(Frontiers in Genetics, 2022)
Parkinson’s disease is a neurodegenerative disorder with a heterogeneous genetic etiology. The advent of next-generation sequencing (NGS) technologies has aided novel gene discovery in several complex diseases, including ...
In silico repurposing of a Novobiocin derivative for activity against latency associated Mycobacterium tuberculosis drug target nicotinate-nucleotide adenylyl transferase (Rv2421c)
(Public Library of Science, 2021)
Nicotinamide-nucleotide adenylyl transferase (Rv2421c) was selected as a potential drug
target, because it has been shown, in vitro, to be essential for Mycobacterium tuberculosis
growth. It is conserved between mycobacterium ...
The combat-tb workbench: Making powerful Mycobacterium tuberculosis bioinformatics accessible
(American Society for Microbiology, 2022)
Whole-genome sequencing (WGS) is a powerful method for detecting drug resistance, genetic diversity, and transmission dynamics of Mycobacterium tuberculosis. Implementation of WGS in public health microbiology laboratories ...
A view on genomic medicine activities in Africa: Implications for policy
(Frontiers Media, 2022)
Genomics policy development involves assessing a wide range of issues extending from
specimen collection and data sharing to whether and howto utilize advanced technologies in
clinical practice and public health initiatives. ...
Repurposing based identification of novel inhibitors against mmps5-mmpl5 efflux pump of Mycobacterium smegmatis: A combined in silico and in vitro study
(MDPI, 2022)
In the current era of a pandemic, infections of COVID-19 and Tuberculosis (TB) enhance
the detrimental effects of both diseases in suffering individuals. The resistance mechanisms evolving
in Mycobacterium tuberculosis ...
Selection analysis identifies clusters of unusual mutational changes in omicron lineage ba.1 that likely impact spike function
(Oxford University Press, 2022)
Among the 30 nonsynonymous nucleotide substitutions in the Omicron S-gene are 13 that have only rarely been seen
in other SARS-CoV-2 sequences. These mutations cluster within three functionally important regions of the ...