Browsing by Title
Now showing items 1188-1207 of 7879
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Computational approaches for the design of novel anticancer compounds based on pyrazolo[3,4-d]pyrimidine derivatives as trap1 inhibitor
(Switzerland: MDPI AG, 2021)In the present in-silico study, various computational techniques were applied to determine potent compounds against TRAP1 kinase. The pharmacophore hypothesis DHHRR_1 consists of important features required for activity. ... -
Computational approaches for the design of novel anticancer compounds based on pyrazolo[3,4-d]pyrimidine derivatives as trap1 inhibitor
(MPDI, 2021)In the present in-silico study, various computational techniques were applied to determine potent compounds against TRAP1 kinase. The pharmacophore hypothesis DHHRR_1 consists of important features required for activity. ... -
Computational characterization of iron metabolism in the tsetse disease vector, glossina morsitans: Ire stem-loops
(BMC, 2016)Iron metabolism and regulation is an indispensable part of species survival, most importantly for blood feeding insects. Iron regulatory proteins are central regulators of iron homeostasis, whose binding to iron response ... -
Computational drug repurposing strategy predicted peptide-based drugs that can potentially inhibit the interaction of SARS-CoV 2 spike protein with its target (humanACE2
(Public Library of Science, 2020)Drug repurposing for COVID-19 has several potential benefits including shorter development time, reduced costs and regulatory support for faster time to market for treatment that can alleviate the current pandemic. The ... -
Computational insight of dexamethasone against potential targets of SARS-CoV-2
(Taylor and Francis Group, 2022)The health sector has been on the race to find a potent therapy for coronavirus disease (COVID)-19, a diseases caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2. Repurposed anti-viral drugs have played ... -
(Con)texturing ideologies of modesty, authority, and childbearing in 1 Timothy 2:8–15
(Taylor and Francis Group, 2022)Feminist and gender critical biblical scholarship hasshown how texts ideologically function as products of their ancient social and cultural norms. In my dissertation work on Pauline texts, through isolating ... -
Concept mapping: Stakeholders perceptions of what should be included in interventions programmes aimed at reducing engagement in health risk behaviour amongst youth
(African Association for Health, Physical Education, Recreation, Sport and Dance (AFAHPER-SD), 2014)Engagement in health risk behaviours (HRBs) amongst young people is increasing despite numerous programmes to address such behaviours. The active engagement of multiple stakeholder groups, including youth, in articulating ... -
The conceptual evolution in Linguistics implications for the study of Kaaps
(University of the Westen Cape, 2020)zaAbstractAs an academic discipline, Linguistics - the scientific study of language - is associated with a range of concepts. Students of Linguistics are traditionally introduced to these concepts in their first year of ... -
A conceptual framework for cost management training in the Limpopo Province of South Africa
(Journal of Nursing Management, 2013)This paper describes the perceptions of nurse managers about their dual role in nursing units as cost centres. -
Conceptual framework for establishing the African Stroke Organization
(SAGE, 2021)Africa is the world’s most genetically diverse, second largest, and second most populous continent, with over one billion people distributed across 54 countries. With a 23% lifetime risk of stroke, Africa has some of the ... -
A conceptual framework for sustainable waste management in small municipalities: The cases of Langebaan, South Africa and Swakopmund, Namibia
(Springer, 2023)Municipal waste management is a major challenge for local governments in South Africa and Namibia, as in other developing countries. The circular economy concept in waste management is an alternative sustainable development ... -
A conceptual framework of the resemblance in self-leadership and professional core values of nurses in the South African context
(AFAHPER-SD, 2014)In a country such as South Africa with its widely diverse values and belief systems, it could be a challenge to bring about a common understanding of professionalism amongst nurses in a multicultural society. When novice ... -
A conceptual model for the development and management of the Cape Flats aquifer, South Africa
(Water Research Commission, 2010)This paper provides an integrated approach to the analysis of the geological, hydrological and hydrogeological characteristics of the Cape Flats: a coastal plain sand formed within the mountains of the Cape Town metropolitan ... -
Conceptual research on the term facilitation: reducing an elephant to chewable chunks
(University of Stellenbosch, 2007)Aim of the article: With this article the researchers used a conceptual research process to: explore the meanings of the concept of facilitation; identify the key facilitating actions/behaviours of the facilitator and the ... -
Conceptualisations of childhood in Namibia: new legislation versus public perception
(University of the Western Cape, 2010)BACKGROUND: Namibia is in the process of developing new children's legislation. The aim of this research paper is to explore how the public conceptualisation of childhood in Namibia compares to provisions in the Child ... -
Conceptualising COVID-19’s impacts on household food security
(Springer, 2020)COVID-19 undermines food security both directly, by disrupting food systems, and indirectly, through the impacts of lockdowns on household incomes and physical access to food. COVID-19 and responses to the pandemic could ... -
Conceptualising COVID-19’s impacts on household food security
(Springer Nature, 2020)COVID-19 undermines food security both directly, by disrupting food systems, and indirectly, through the impacts of lockdowns on household incomes and physical access to food. COVID-19 and responses to the pandemic could ... -
Conceptualising the factors affecting retention in care of patients on antiretroviral treatment in Kabwe District, Zambia, using the ecological framework
(Hindawi Publishing Corporation, 2017)BACKGROUND. HIV remains a major public health challenge in Zambia.The roll-out of antiretroviral treatment (ART) has engendered new challenges in retention in care. OBJECTIVE. To conceptualise the factors affecting retention ... -
Concerns about physical inactivity among adolescents in the Strand, South Africa
(University of the Western Cape, 2006)INTRODUCTION: Strong evidence exist to support the assumption that regular physical activity is one of the most cost effective interventions for the prevention and management of chronic diseases of lifestyle, and should ... -
The conditional early release of offenders transferred from the Special Court for Sierra Leone to serve their sentences in designated states: some observations and recommendations
(Juta Law, 2014)The Special Court for Sierra Leone (SCSL) (now the Residual Special Court for Sierra Leone) convicted various offenders of crimes, such as war crimes and crimes against humanity. These convicted offenders were sentenced ...
