Browsing by Author "Fisher, David W."
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Are claudin-5 tight-junction proteins in the blood-brain barrier porous?
Fisher, David W.; Mentor, Shireen (Wolters Kluwer Health, 2020)The capillaries of the brain are particularly special, as they are not simply conduits for blood, but are primarily responsible to ensure that the neurons function in a strictly regulated homeostatic interstitium. Brain ... -
Permeation challenges of drugs for treatment of neurological tuberculosis and HIV and the application of magneto-electric nanoparticle drug delivery systems
Fisher, David W.; Tchoula Tchokonte, Moise B.; Dube, Admire; Mhambi, Sinaye (MDPI, 2021)The anatomical structure of the brain at the blood-brain barrier (BBB) creates a limitation for the movement of drugs into the central nervous system (CNS). Drug delivery facilitated by magneto-electric nanoparticles (MENs) ... -
The synergistic and neuroprotective effects of alcohol–antioxidant treatment on blood–brain barrier endothelial cells
Fisher, David W.; Thomas, Kelly Angelique; Abdul-Rasool, Sahar (Wiley-Blackwell, 2020)Background: Alcohol (EtOH) is reported to adversely affect one of the most crucial roles of the blood–brain barrier (BBB), the regulation of its permeability, thereby compromising the stability of the homeostatic environment ...