Browsing by Author "Johnson, Rabia"
Now showing items 1-3 of 3
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Cross-sectional study of the association of 5 single nucleotide polymorphisms with enalapril treatment response among South African adults with hypertension
Masilela, Charity; Pearce, Brendon; Ongole, Joven J.; Adeniyi, Oladele V.; Johnson, Rabia; Benjeddou, Mongi (NLM (Medline), 2021-11-19)This study investigates the association of 5 single nucleotide polymorphisms (SNPs) in selected genes (ABO, VEGFA, BDKRB2, NOS3, and ADRB2) with blood pressure (BP) response to enalapril. The study further assessed genetic ... -
The determination of the effect(s) of solute carrier family 22‑member 2 (SLC22A2) haplotype variants on drug binding via molecular dynamic simulation systems
Abrahams-October, Zainonesa; Johnson, Rabia; Cloete, Ruben (Nature Research, 2022)Single nucleotide polymorphisms detected in the solute carrier member family-22 has been shown to result in a variable response in the treatment of type 2 diabetes mellitus with Metformin. This study predicted a ... -
An in vitro study on the combination effect of metformin and N-Acetyl cysteine against hyperglycaemia-Induced cardiac damage
Mabhida, Sihle E.; Johnson, Rabia; Sangweni, Nonhlakanipho F.; Dludla, Phiwayinkosi V. (MDPI, 2019-11-21)Chronic hyperglycaemia is a major risk factor for diabetes-induced cardiovascular dysfunction. In a hyperglycaemic state, excess production of reactive oxygen species (ROS), coupled with decreased levels of glutathione, ...