Browsing by Author "Berry, Michael"
Now showing items 1-5 of 5
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Characterisation of human coronavirus-NL63 nucleocapsid protein
Berry, Michael; Manasse, Taryn-Lee; Tan, Yee-Joo; Fielding, Burtram C. (Academic Journals, 2012)Coronavirus N is a multifunctional protein that plays an essential role in enhancing the efficiency of virus transcription and assembly. This manuscript reports the analysis of HCoV-NL63 N protein by comparing the amino ... -
Human coronavirus OC43 3CL protease and the potential of ML188 as a broad-spectrum lead compound: Homology modelling and molecular dynamic studies
Berry, Michael; Fielding, Burtram; Gamieldien, Junaid (Springer Nature, 2015)The coronavirus 3 chymotrypsin-like protease (3CLpro) is a validated target in the design of potential anticoronavirus inhibitors. The high degree of homology within the protease’s active site and substrate conservation supports ... -
Identification of new respiratory viruses in the new millennium
Berry, Michael; Gamieldien, Junaid (MDPI, 2015)The rapid advancement of molecular tools in the past 15 years has allowed for the retrospective discovery of several new respiratory viruses as well as the characterization of novel emergent strains. The inability to ... -
Potential broad spectrum inhibitors of the coronavirus 3CLpro: a virtual screening and structure-based drug design study
Berry, Michael; Fielding, Burtram C. (MDPI, 2015)Human coronaviruses represent a significant disease burden; however, there is currently no antiviral strategy to combat infection. The outbreak of severe acute respiratory syndrome (SARS) in 2003 and Middle East respiratory ... -
Potential broad spectrum inhibitors of the coronavirus 3CLpro: A virtual screening and structure-based drug design study
Berry, Michael; Fielding, Burtram C.; Gamieldien, Junaid (MDPI, 2015)Human coronaviruses represent a significant disease burden; however, there is currently no antiviral strategy to combat infection. The outbreak of severe acute respiratory syndrome (SARS) in 2003 and Middle East respiratory ...