Browsing by Author "Saunders, Colleen J."
Now showing items 1-7 of 7
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Application of an in silico approach identifies a genetic locus within ITGB2, and its interactions with HSPG2 and FGF9, to be associated with anterior cruciate ligament rupture risk
Dlamini, Senanile B.; Saunders, Colleen J.; Laguette, Mary-Jessica N. (Taylor and Francis Group, 2023)We developed a Biomedical Knowledge Graph model that is phenotype and biological functionaware through integrating knowledge from multiple domains in a Neo4j, graph database. All known human genes were assessed through ... -
Application of anin silicoapproach identifies a genetic locus withinITGB2,and itsinteractions withHSPG2 and FGF9,to be associated with anterior cruciateligament rupture risk
Dlamini, Senanile B.; Saunders, Colleen J.; Gamieldien, Junaid (Taylor and Francis Group, 2023)We developed a Biomedical Knowledge Graph model that is phenotype and biological function-aware through integrating knowledge from multiple domains in a Neo4j, graph database. Allknown human genes were assessed through the ... -
Defining the molecular signatures of Achilles tendinopathy and anterior cruciate ligament ruptures: A whole-exome sequencing approach
Gibbon, Andrea; Saunders, Colleen J.; Collins, Malcolm; Gamieldien, Junaid; September, Alison V. (Public Library of Science, 2018)Musculoskeletal soft tissue injuries are complex phenotypes with genetics being one of many proposed risk factors. Case-control association studies using the candidate gene approach have predominately been used to identify ... -
Designing a course model for distance-based online bioinformatics training in Africa: the H3ABioNet experience
Gurwitz, Kim T.; Aron, Shaun; Entfellner, Jean-Baka Domelevo; Saunders, Colleen J.; Cloete, Ruben (Public Library of Science, 2017)Africa is not unique in its need for basic bioinformatics training for individuals from a diverse range of academic backgrounds. However, particular logistical challenges in Africa, most notably access to bioinformatics ... -
Exploring new genetic variants within col5a1 intron 4‐exon 5 region and tgf‐β family with risk of anterior cruciate ligament ruptures
Laguette, Mary‐Jessica N.; Barrow, Kelly; Saunders, Colleen J. (Wiley, 2020)Variants within genes encoding structural and regulatory elements of ligaments have been associated with musculoskeletal soft tissue injury risk. The role of intron 4‐exon 5 variants within the α1 chain of type V collagen ... -
Semantic interrogation of a multi knowledge domain ontological model of tendinopathy identifies four strong candidate risk genes
Saunders, Colleen J.; Dashti, Mahjoubeh Jalali Sefid; Gamieldien, Junaid (Nature Research, 2016)Tendinopathy is a multifactorial syndrome characterised by tendon pain and thickening, and impaired performance during activity. Candidate gene association studies have identified genetic factors that contribute to ... -
Variants within the COMP and THBS2 genes are not associated with Achilles tendinopathy in a case-control study of South African and Australian populations
Saunders, Colleen J.; Van Der Merwe, Lize; Cook, Jill; Handley, Christopher J.; Collins, Malcolm; September, Alison V. (Taylor & Francis, 2013)Cartilage oligomeric matrix protein is a structural protein of the extracellular matrix, while thrombospondin-2 is a matricellular protein involved in cell–matrix interactions. Recent studies have shown that genetic variation ...