Browsing by Author "Syce, James"
Now showing items 1-5 of 5
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Challenges relating to comparison of flavonoid glycosides dissolution profiles from Sutherlandia frutescens products
Mbamalu, Oluchi; Syce, James; Samsodien, Halima (De Gruyter Open, 2017)Unlike the case of conventional drug formulations, dissolution tests have hitherto not been required for herbal medicinal products commercially available in South Africa. This study investigated dissolution of the South ... -
Exploration of scaffolds from natural products with antiplasmodial activities, currently registered antimalarial drugs and public malarial screen data
Egieyeh, Samuel; Syce, James; Christoffels, Alan; Malan, Sarel F. (MDPI, 2016)In light of current resistance to antimalarial drugs, there is a need to discover new classes of antimalarial agents with unique mechanisms of action. Identification of unique scaffolds from natural products with in vitro ... -
HPLC determination of selected flavonoid glycosides and their corresponding aglycones in Sutherlandia frutescens materials
Mbamalu, Oluchi; Antunes, E.; Silosini, N.; Samsodien, Halima; Syce, James (OMICS, 2016)Sutherlandia frutescens is a popular South African plant commercially available in a range of formulations. However, reference standards for quality and stability assessment are lacking. This work reports the development and ... -
Predictive classifier models built from natural products with antimalarial bioactivity using machine learning approach
Egieyeh, Samuel; Syce, James; Malan, Sarel F.; Christoffels, Alan (Public Library of Science, 2018)In view of the vast number of natural products with potential antiplasmodial bioactivity and cost of conducting antiplasmodial bioactivity assays, it may be judicious to learn from previous antiplasmodial bioassays and ... -
Prioritization of anti-malarial hits from nature: Chemo-informatic profiling of natural products with in vitro antiplasmodial activities and currently registered anti-malarial drugs
Egieyeh, Samuel Ayodele; Syce, James; Malan, Sarel F. (BMC, 2016)A large number of natural products have shown in vitro antiplasmodial activities. Early identification and prioritization of these natural products with potential for novel mechanism of action, desirable pharmacokinetics ...