Browsing Faculty of Natural Sciences by Title
Now showing items 107-126 of 2571
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Antimicrobial resistance screening and profiles: A glimpse from the South African perspective
(IWA Publishing, 2020)According to the Centre for Disease Dynamics Economics and Policy, South Africa represents a paradox of antibiotic management similar to other developing countries, with both overuse and underuse (resulting from lack of ... -
Antimicrobial resistant Gram-positive cocci in pregnant mothers with aerobic vaginitis
(Infection Control Africa Network (ICAN), 2016)The vaginal microbiota of a healthy asymptomatic woman consists of an extensive diversity of anaerobic and aerobic bacterial genera and species dominated by the microaerophilic genus Lactobacillus , known to inhibit the ... -
Antimicrobial-resistant Klebsiella species isolated from free-range chicken samples in an informal settlement
(Termedia Publishing House, 2012)Sub-therapeutic doses of antimicrobial agents are administered routinely to poultry to aid growth and to prevent disease, with prolonged exposure often resulting in bacterial resistance. Crossover of antibiotic resistant ... -
Antimycobacterial activity and molecular docking of methanolic extracts and compounds of marine fungi from Saldanha and False Bays, South Africa
(Elsevier, 2022)The number and diversity of drugs in the tuberculosis (TB) drug development process has increased over the years, yet the attrition rate remains very high, signaling the need for continued research in drug discovery. In ... -
Antimycobacterial Activity, Synergism, and Mechanism of Action Evaluation of Novel Polycyclic Amines against Mycobacterium tuberculosis
(Advances in Pharmacological and Pharmaceutical Sciences, 2021-06)Mycobacterium tuberculosis has developed extensive resistance to numerous antimycobacterial agents used in the treatment of tuberculosis. Insufficient intracellular accumulation of active moieties allows for selective ... -
Antinociceptive and anti-Inflammatory activities of leaf methanol extract of cotyledon orbiculata L. (Crassulaceae)
(Hindawi, 2012)Leaf methanol extract of C. orbiculata L. was investigated for antinociceptive and anti-inflammatory activities using acetic acid writhing and hot-plate tests and carrageenan-induced oedema test in mice and rats, respectively. ... -
Antinociceptive, anti-inflammatory and antipyretic activities of the leaf methanol extract of ruta graveolens l. (rutaceae) in mice and rats
(African Networks Ethnomedicines, 2014)Ruta graveolens has been used to treat toothache, earache, rheumatism and fever with little scientific evidence corroborating these uses. The leaf methanol extract of Ruta graveolens was evaluated for antinociceptive ... -
Antioxidant and apoptosis-inhibition potential of Carpobrotus edulis in a model of parkinson’s disease
(African Association of Physiological Sciences, 2018)Background: Parkinson’s disease (PD) is a neurological disorder resulting from the progressive loss of dopaminergic neurons. There is currently no known cure for PD, thus the search for complementary and alternative medicines ... -
The antioxidant and in vitro wound healing activity of cotyledon orbiculata aqueous extract and the synthesized biogenic silver nanoparticles
(MDPI, 2022)The synthesis of silver nanoparticles using biogenic methods, particularly plants, has led to the discovery of several effective nanoparticles. In many instances, plant-derived silver nanoparticles have been shown to ... -
Antioxidant responses are associated with differences in drought tolerance between maize and sorghum
(Arid land institute, 2021)Drought is a major cause of decreased yield in crops worldwide. Sorghum (Sorghum bicolor) and maize (Zea mays) are two of the key crops in Africa serving as human food as well as livestock feed. For improved crop ... -
An∼600 pc View of the Strongly Lensed, Massive Main-sequence Galaxy J0901: A Baryon-dominated, Thick Turbulent Rotating Disk with a Clumpy Cold Gas Ring at z=2.259
(Institute of Physics, 2023)We present a high-resolution kinematic study of the massive main-sequence star-forming galaxy (SFG) SDSS J090122.37+181432.3 (J0901) at z = 2.259, using ∼0 36 Atacama Large Millimeter/submillimeter Array CO(3–2) and ∼0 ... -
An∼600 pc view of the strongly lensed, massive main-sequence galaxy j0901: A baryon-dominated, thick turbulent rotating disk with a clumpy cold gas ring at z=2.259
(American Astronomical Society, 2023)We present a high-resolution kinematic study of the massive main-sequence star-forming galaxy (SFG) SDSS J090122.37+181432.3 (J0901) at z = 2.259, using ∼0 36 Atacama Large Millimeter/submillimeter Array CO(3–2) and ∼0 ... -
Apoptosis in cancer cells is induced by alternative splicing of hnrnpa2/b1 through splicing of bcl-x, a mechanism that can be stimulated by an extract of the South African medicinal plant, cotyledon orbiculata
(Frontiers Media S.A., 2020)Alternative splicing is deregulated in cancer and alternatively spliced products can be linked to cancer hallmarks. Targeting alternative splicing could offer novel effective cancer treatments. We investigated the effects ... -
Application of an in silico approach identifies a genetic locus within ITGB2, and its interactions with HSPG2 and FGF9, to be associated with anterior cruciate ligament rupture risk
(Taylor and Francis Group, 2023)We developed a Biomedical Knowledge Graph model that is phenotype and biological functionaware through integrating knowledge from multiple domains in a Neo4j, graph database. All known human genes were assessed through ... -
Application of anin silicoapproach identifies a genetic locus withinITGB2,and itsinteractions withHSPG2 and FGF9,to be associated with anterior cruciateligament rupture risk
(Taylor and Francis Group, 2023)We developed a Biomedical Knowledge Graph model that is phenotype and biological function-aware through integrating knowledge from multiple domains in a Neo4j, graph database. Allknown human genes were assessed through the ... -
Application of fundamental techniques for physicochemical characterizations to understand post-formulation performance of pharmaceutical nanocrystalline materials
(MPDI, 2021)Nanocrystalline materials (NCM, i.e., crystalline nanoparticles) have become an important class of materials with great potential for applications ranging from drug delivery and electronics to optics. Drug nanocrystals ... -
Application of multi‑method approach to assess groundwater–surface water interactions, for catchment management
(Springer, 2018)Globally, the dependence of river systems to delayed discharge of subsurface water to augment flows during dry seasons is well documented. Discharge of fresh subsurface water can dilute concentrated river flow quality ... -
Application of nano zinc oxide (nZnO) for the removal of triphenyltin chloride (TPT) from dockyard wastewater
(Water Research Commission, 2014)The use of triphenyltin chloride (TPT), a persistent organic pollutant, as a biocide has led to serious contamination of the marine environment. The potential of nano zinc oxide (nZnO) for the removal of TPT from contaminated ... -
Application of seismic stratigraphy in reservoir characterisation: A case study of the passive margin deposits of the northern Orange Basin, South Africa
(Springer Nature, 2020)The Barremian-Cenozoic depositional sequences in the northern Orange Basin, SW, South Africa, were investigated using the principles of seismic stratigraphy to understand the interplay of tectonics and sedimentary processes ... -
Application of surface-modified metal hydrides for hydrogen separation from gas mixtures containing carbon dioxide and monoxide
(Elsevier, 2013)Application of surface-modified MH material for H2 separation using temperature/pressure swing absorption–desorption was studied. The substrate alloy had the following composition LaNi3.55Co0.75Al0.4-Mn0.3, and the surface ...